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Inhibition of PKC (unknown origin) using acetylated myelin basic protein (4 to 14 residues) as substrate incubated for [gamma-32P]-ATP incubated for 5 mins by scintillation counter analysis
Assay data:1 Tested
SummaryRelated BioAssays by Target
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 100 nM incubated for 15 mins by immunoblotting analysis
Assay data:1 Active, 1 Tested
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 0.1 to 10 uM incubated for 15 mins by immunoblotting analysis
Assay data:3 Tested
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation at 10 uM pretreated with PMA for 24 hrs followed by compound addition and measured after 15 mins by immunoblotting analysis
Activation of PKC in human THP-1 cells assessed as increase in ERK phosphorylation incubated for 15 mins by immunoblotting analysis
Assay data:2 Tested
Inhibition of PKC (unknown origin)
Inhibition of Protein kinase C (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
Inhibition of human PKC
In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000154b PRKCH
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000296b PRKCE
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000328a PRKCE
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000749a PRKCE
Affinity Biochemical interaction (Filter-binding assays) EUB0000154b PRKCE
Affinity Phenotypic Cellular interaction (Antiproliferation against diverse cancer cell lines (HCT116; PC3-prostate cacinoma cell and U87MG glioblastoma cells)) EUB0000154b PRKCE
Inhibition of PKCeta (unknown origin) at 1 uM in presence of ATP at Km concentration by mobility shift assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PKCeta (unknown origin) by Z'LYTE screening method relative to control
Inhibition of PKCepsilon (unknown origin) by Z'LYTE screening method relative to control
Inhibition of PKCepsilon (unknown origin) by IMAP kinase assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
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