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Enzymatic Activity Test from US Patent US20240228491: "METHIONINE ADENOSYLTRANSFERASE INHIBITOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF"
Assay data:88 Active, 88 Activity ≤ 1 µM, 88 Tested
SummaryRelated BioAssays by Target
Biochemical Assay from US Patent US20240124454: "TRICYCLIC COMPOUND AND USE THEREOF"
Assay data:82 Active, 82 Activity ≤ 1 µM, 82 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Measurement of Mat2A inhibition is performed in 384 well format absorbance-based assay from US Patent US20230382911: "PYRAZOLEAMIDE DERIVATIVES"
Assay data:78 Active, 78 Activity ≤ 1 µM, 78 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of MT2A in MTAP-null human HCT-116 cells after 72 hrs by LC-MS/MS analysis relative to control
Assay data:13 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MT2A in MTAP-null human HCT-116 cells after 72 hrs by LC-MS/MS analysis
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins in presence of ATP relative to control
Assay data:16 Tested
Inhibition of recombinant human MAT2A expressed in baculovirus infected Sf9 cells assessed as S-adenosyl methionine production using L-methionine as substrate preincubated for 60 mins followed by substrate addition and measured after 60 mins in presence of ATP
Assay data:16 Active, 12 Activity ≤ 1 µM, 16 Tested
Inhibition of human MAT2A assessed as S-adenosyl methionine production using L-methionine as substrate pretreated for 60 mins followed by L-methionine and ATP addition by colorimetric analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of MAT2A (unknown origin) assessed as S-adenosyl methionine production using L-methionine as substrate pretreated for 60 mins followed by L-methionine and ATP addition
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human MAT2A expressed in baculovirus infected Sf9 cells expression system assessed as S-adenosyl methionine production using L-methionine as substrate pretreated for 60 mins followed by L-methionine and ATP addition
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
Inhibition of MAT2A in human Huh-7 cells assessed as inhibition of S-adenosyl methionine production measured after 6 hrs by Rapid Fire Mass Spectrometry analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of MAT2A in human NCI-H520 cells transfected with MAT2A empty vector assessed as inhibition of S-adenosyl methionine production measured after 6 hrs by Rapid Fire Mass Spectrometry analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of N-terminal TEV cleavable 6His-tagged human MAT2A (1 to 395 residues) expressed in Escherichia coli BL21 (DE3) cells assessed as S-adenosyl methionine production using L-methionine as substrate incubated for 30 mins followed by L-methionine and ATP addition by MS/MS analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human recombinant His-tagged MAT2A expressed in Escherichia coli expression system assessed as S-adenosyl methionine production using L-methionine as substrate incubated for 20 mins followed by L-methionine and ATP addition by malachite green phosphate assay
Assay data:2 Active, 2 Tested
Inhibition of full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli using methionine and ATP as substrate incubated for 90 mins by biomol green reagent based assay
Assay data:10 Active, 6 Activity ≤ 1 µM, 33 Tested
Binding affinity to full length recombinant human N-terminal His6-tagged MAT2A expressed in Escherichia coli assessed as dissociation constant by SPR analysis
Assay data:1 Active, 4 Tested
Phosphate Sensor Fluorescence Assay from US Patent US11130759: "2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors"
Assay data:610 Active, 590 Activity ≤ 1 µM, 657 Tested
Malachite Green Assay from US Patent US11130759: "2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors"
Assay data:61 Active, 56 Activity ≤ 1 µM, 61 Tested
Biochemical Assay from US Patent US11084798: "2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors"
Assay data:666 Active, 640 Activity ≤ 1 µM, 713 Tested
Phosphate Sensor Fluorescence Assay from US Patent US11046691: "2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors"
Assay data:620 Active, 599 Activity ≤ 1 µM, 667 Tested
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