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TTK SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of human full-length N-terminal GST-tagged MPS1 using FITC-labeled peptide as substrate incubated for 1 hr by Fluorescence based analysis
Inhibition of human TTK
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human TTK by TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
TTK Enzyme Assay from US Patent US11884671: "Purinone compounds and their use in treating cancer"
Assay data:46 Active, 22 Activity ≤ 1 µM, 51 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Selectivity interaction (SelectScreen (Invitrogen)) EUB0000715a TTK
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000138c TTK
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000691a TTK
Affinity Biochemical interaction (LanthaScreen Eu kinase binding assay) EUB0000642a TTK
Affinity Biochemical interaction (TR-FRET-based in vitro kinase assays) EUB0000634a TTK
Affinity Biochemical interaction (Ambit Competition binding assay) EUB0000609a TTK
Affinity Biochemical interaction (Ambit Competition binding assay) EUB0000608a TTK
Affinity Phenotypic Cellular interaction (Western Blot (phosphorylation of TTK T686 in Cal-51 cells)) EUB0000642a TTK
Affinity Phenotypic Cellular interaction (Mps1 kinase phosphorylation assay (abolished KNL1 Thr-875 phosphorylation in A2780 cells pretreated with 100 nmol/L paclitaxel)) EUB0000634a TTK
Affinity Phenotypic Cellular interaction (Immunoblot activity assay (using LAP-Mps1 WT in U2OS cells)) EUB0000609a TTK
Affinity Phenotypic Cellular interaction (Immunoblot activity assay (using LAP-Mps1 WT in U2OS cells)) EUB0000608a TTK
Thermal Shift Assay. Domain: start/stop: S519-E808
Assay data:27 Tested
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