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Biological Assay from US Patent US20240182466: "A Crystal Form of a Fluorine-substituted Pyridopyrazole Compound and a Preparation Method Thereof"
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of GST-tagged human recombinant TXK (260 to 527 residues) expressed in baculovirus expression system at 200 nM by Z'-lyte assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TXK (unknown origin) at 1 uM relative to control
Inhibition of TEC (unknown origin) at 500 nM relative to control
Inhibition of TXK (unknown origin) at 500 nM relative to control
Inhibition of TEC (unknown origin) by Ambit kinase assay
Inhibition of TXK (unknown origin)
Inhibition of FLAG-tagged TEC autophosphorylation in HEK293 cells incubated for 2 hrs by MSD electrochemiluminescence immunoassay
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human TEC preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay
Inhibition of human TXK preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of TEC (unknown origin) preincubated for 1 hrs followed by substrate addition and measured after 1 hrs in the presence of ATP at Km concentration by TR-FRET assay
Assay data:28 Active, 29 Activity ≤ 1 µM, 29 Tested
Inhibition of TEC (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of human TEC at 1 uM by hotspot assay relative to control
Inhibition of human TXK at 1 uM by hotspot assay relative to control
Selectivity interaction (p-TEC MSD assay) EUB0000646a TEC
Selectivity interaction (33P-ATP and filter-binding assay (Reaction Biology)) EUB0000646a TEC
Selectivity interaction (KinaseProfiler? (Millipore)) EUB0000640a TXK
SummaryRelated BioAssays by Target
Selectivity interaction (Z?-LYTE assay) EUB0000638a TXK
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