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STK17A SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of DRAK1 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human partial length wild type DRAK1 expressed in bacterial system at 1 uM by KINOMEscan analysis relative to control
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000305b STK17A
Selectivity interaction (KinomeScan (DiscoverX)) EUB0000305b STK17A
Selectivity interaction (Enzymatic assay (Eurofins)) EUB0000305b STK17A
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000305b STK17A
Selectivity interaction (Enzymatic assay) EUB0000305b STK17A
Selectivity interaction (Kinase panel (ProQinase)) EUB0000631a STK17A
Selectivity interaction (Upstate Kinase Profiler service (Millipore)) EUB0000056c STK17A
Thermal Shift Assay. Domain: start/stop: V50-P350
Assay data:27 Tested
Inhibition of human N-terminal His-tagged/ TEV cleavage fused DRAK1 (39 to 369 residues) expressed in Escherichia coli assessed as gibbs free energy change by isothermal titration calorimetry
Assay data:2 Tested
Inhibition of human N-terminal His-tagged/ TEV cleavage fused DRAK1 (39 to 369 residues) expressed in Escherichia coli assessed as change in entropy by isothermal titration calorimetry
Inhibition of human N-terminal His-tagged/ TEV cleavage fused DRAK1 (39 to 369 residues) transfected in HEK293T cells using NanoBRET NanoGlo as substrate incubated for 2 hrs by NanoBRET assay
Assay data:5 Active, 5 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human N-terminal His-tagged/ TEV cleavage fused DRAK1 (39 to 369 residues) expressed in Escherichia coli using KKLNRTLSFAEPG peptide as substrate in presence of [gamma-33P]ATP by radiometric based scintillation proximity assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Binding affinity to human N-terminal His-tagged/ TEV cleavage fused DRAK1 (39 to 369 residues) expressed in Escherichia coli by isothermal titration calorimetry
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to human N-terminal His-tagged/ TEV cleavage fused DRAK1 (39 to 369 residues) expressed in Escherichia coli assessed as change in melting temperature at 10 uM by SYPRO orange dye based DSF assay
Assay data:7 Tested
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