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NanoBRET assay (FLT3, SGC Frankfurt)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of FLT3 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of FLT3 autophosphorylation at Tyr589/591 residue in human MV4-11 cells harboring FLT3-ITD mutant at 0.3 uM incubated for 4 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of FLT3 autophosphorylation at Tyr589/591 residue in human MOLM-14 cells harboring FLT3-ITD mutant at 1 uM incubated for 4 hrs by Western blot analysis
Inhibition of FLT3 autophosphorylation at Tyr589/591 residue in human MOLM-13 cells harboring FLT3-ITD mutant at 1 uM incubated for 4 hrs by Western blot analysis
Inhibition of FLT3 ITD mutant (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FLT3 (unknown origin) preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assay
Inhibition of FLT3 ITD mutant (unknown origin) assessed as residual activity at 1 uM preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assay relative to control
Inhibition of FLT3 (unknown origin) assessed as residual activity at 1 uM preincubated for 60 mins followed by ATP addition and measured after 1 hr by ADP-Glo assay relative to control
Inhibition of Flt3 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
Inhibition of FLT3 (unknown origin) at 1 uM relative to control
Inhibition of FLT3 (unknown origin) by discoverX kinomescan assay
Inhibition of FLT3 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human recombinant GST-fused FLT3 expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:2 Active, 2 Tested
Inhibition of FLT3 D835V mutant (unknown origin) at 1 uM by Kinomescan assay relative to staurosporine
Inhibition of FLT3 (unknown origin) in presence of 600 uM ATP
Assay data:5 Active, 3 Activity ≤ 1 µM, 6 Tested
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