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Inhibition of mTORC1 reactivation in human ARPE-19 cells at 25 to 50 uM preincubated for 4 hrs under starvation/refeed condition measured after 1 hr in complete medium by Western blot analysis
Assay data:2 Active, 2 Tested
SummaryRelated BioAssays by Target
Inhibition of mTORC1 reactivation in human ARPE-19 cells assessed as reduction of P70 phosphorylation at 10 uM preincubated for 4 hrs under starvation/refeed condition measured after 1 hr in complete medium by Western blot analysis
Assay data:1 Active, 2 Tested
Inhibition of mTORC1 reactivation in human ARPE-19 cells assessed as reduction of 4E-BP1 phosphorylation at 10 uM preincubated for 4 hrs under starvation/refeed condition measured after 1 hr in complete medium by Western blot analysis
Inhibition of mTORC1 in human ARPE19 cells assessed as decrease in P70/total P70 phosphorylation level at 10 uM measured after 4 hrs by Western blot analysis
Inhibition of mTORC1 in human ARPE19 cells measured after 4 hrs by Western blot analysis
Assay data:2 Tested
Inhibition of mTORC1 in human ARPE19 cells at 10 to 50 uM measured after 4 hrs by Western blot analysis related to control
Invivo inhibition of mTOR in human MCF7 cells xenografted in athymic nude mouse assessed as downregulation of phosphorylated S6K level at 10 mg/kg, iv
Assay data:1 Active, 1 Tested
Invivo inhibition of mTOR in human MDA-MB-231/GFP cells xenografted in athymic nude mouse assessed as downregulation of phosphorylated S6K level at 10 mg/kg, iv
Invivo inhibition of mTOR in human MCF7 cells xenografted in athymic nude mouse assessed as downregulation of phosphorylated 4E-BP1 level at 10 mg/kg, iv
Invivo inhibition of mTOR in human MDA-MB-231/GFP cells xenografted in athymic nude mouse assessed as downregulation of phosphorylated 4E-BP1 level at 10 mg/kg, iv
Inhibition of mTORC2 in human MDA-MB-231 cells assessed as reduction in Akt phosphorylation at Ser473 residue at 0.25 to 0.5 uM by Western blot analysis
Inhibition of mTORC2 in human MCF7 cells assessed as reduction in Akt phosphorylation at Ser473 residue at 0.25 to 0.5 uM by Western blot analysis
Inhibition of mTOR in human MDA-MB-231 cells assessed as reduction in phosphorylated 4E-BP1 level at 0.25 to 0.5 uM by Western blot analysis
Inhibition of mTOR in human MFC7 cells assessed as reduction in phosphorylated 4E-BP1 level at 0.25 to 0.5 uM by Western blot analysis
Inhibition of mTOR in human MDA-MB-231 cells assessed as reduction in p-S6K level at 0.25 to 0.5 uM by Western blot analysis
Inhibition of mTOR in human MFC7 cells assessed as reduction in p-S6K level at 0.25 to 0.5 uM by Western blot analysis
Inhibition of mTORC2 in human MCF7 cells assessed as reduction in Akt phosphorylation at Ser473 residue at 15 to 25 uM by Western blot analysis
Inhibition of mTORC2 in human MDA-MB-231 cells assessed as reduction in Akt phosphorylation at Ser473 residue at 15 to 25 uM by Western blot analysis
Inhibition of mTOR in human MFC7 cells assessed as reduction in p-S6K level at 15 to 25 uM by Western blot analysis
Inhibition of mTOR in human MFC7 cells assessed as reduction in phosphorylated 4E-BP1 level at 15 to 25 uM by Western blot analysis
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