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hPrep Inhibition Assay from US Patent US20230406840: "N-(2-(3-CYANO-2-AZABICYCLO[3.1.0]HEXAN-2-YL)-2-OXOETHYL)QUINOLINE-4-CARBOXAMIDES"
Assay data:2 Active, 2 Activity ≤ 1 µM, 45 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
hPrep Inhibition Assay from US Patent US20230312550: "N-(2-(4-CYANOTHIAZOLIDIN-3-YL)-2-OXOETHYL)-QUINOLINE-4-CARBOXAMIDES"
Assay data:229 Active, 191 Activity ≤ 1 µM, 229 Tested
In Vitro Inhibition Assay from US Patent US11583516: "Dash inhibitors, and uses related thereto"
Assay data:13 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PREP Enzymatic Activity Assay from US Patent US11504364: "Inhibitors of fibroblast activation protein"
Assay data:43 Active, 42 Activity ≤ 1 µM, 43 Tested
Agonist activity at recombinant human N-terminal His6-tagged PreP expressed in Escherichia coli expression system assessed as increase in degradation of substrate V by measuring catalytic rate at 10 uM measured every 30 sec for 10 mins by fluorometry (Rvb = 1.4 +/- 0.1 /min)
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at recombinant human N-terminal His6-tagged PreP expressed in Escherichia coli expression system assessed as increase in degradation of substrate V by measuring catalytic rate at 1 uM measured every 30 sec for 10 mins by fluorometry (Rvb = 1.4 +/- 0.1 /min)
Agonist activity at recombinant human N-terminal His6-tagged PreP expressed in Escherichia coli expression system assessed as increase in degradation of substrate V by measuring catalytic rate at 0.1 uM measured every 30 sec for 10 mins by fluorometry (Rvb = 1.4 +/- 0.1 /min)
Agonist activity at recombinant human N-terminal His6-tagged PreP expressed in Escherichia coli expression system assessed as increase in degradation of substrate V at 0.0001 to 10 uM measured every 30 sec for 10 mins by fluorometry
Assay data:3 Tested
Agonist activity at recombinant human N-terminal His6-tagged PreP expressed in Escherichia coli expression system assessed as increase in degradation of substrate V by measuring catalytic rate at 0.01 uM measured every 30 sec for 10 mins by fluorometry (Rvb = 1.4 +/- 0.1 /min)
Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) up to 1 uM after 2.5 hrs by Immunoblotting assay
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) after 2.5 hrs by Immunoblotting assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human PreP assessed as degradation of biotin-labeled amyloid beta (1 to 42) after 2.5 hrs by Immunoblotting assay relative to control
Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) at 1 uM after 2.5 hrs by Immunoblotting assay
Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) after 2.5 hrs by Immunoblotting assay relative to control
Agonist activity at human PreP assessed as degradation of ATP synthase pF1beta subunit (2 to 56) after 2.5 hrs by Immunoblotting assay
Agonist activity at human PreP assessed as degradation of fluorogenic substrate V measured for 10 mins by fluorometric analysis
Agonist activity at human PreP assessed as degradation of fluorogenic substrate V at 1 uM measured for 10 mins by fluorometric analysis
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