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Inhibition of human wild type CCR1
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryRelated BioAssays by Target
Inhibition of human recombinant CCR1
Scintillation Proximity Assay from US Patent US11612596: "Pharmaceutical formulations comprising CCR3 antagonists"
Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity Biochemical interaction (Scintillation Proximity Assay (SPA)) EUB0000352a CCR1
Affinity On-target Cellular interaction (Chemotaxis in THP-1 cells) EUB0000352a CCR1
Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000352a CCR1
Affinity Phenotypic Cellular interaction (Functional cellular assay (measuring calcium flux in response to MIP-1a in CCR1-transfected cells)) EUB0000343a CCR1
Assay data:1 Tested
Inhibition of human CCR1 transfected in CHO cells incubated for 1 hr in presence of 125I-chemokine by radioactivity based assay
Assay data:7 Active, 7 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CCR3 (unknown origin) at 10 uM relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CCR1 (unknown origin) at 10 uM relative to control
CCR1 (h) CEREP panel
Antagonist activity against CCR3 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Agonist activity against CCR3 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Antagonist activity against CCR1 (unknown origin) assessed as inhibition of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Agonist activity against CCR1 (unknown origin) assessed as induction of beta-arrestin 2 recruitment at 10 microM by beta arrestin assay relative to control
Scintillation Proximity Assay from US Patent US8742115: "Co-crystals and salts of CCR3-inhibitors"
Assay data:35 Active, 1 Activity ≤ 1 nM, 34 Activity ≤ 1 µM, 35 Tested
Binding Assay from US Patent US8633226: "Piperidinyl derivative as a modulator of chemokine receptor activity"
Assay data:5 Active, 2 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Scintillation Proximity Assay (SPA) from US Patent US8536198: "Piperidine derivatives as modulators of chemokine receptor activity"
Assay data:23 Active, 2 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 23 Tested
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