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Potency index, ratio of diazoxide EC50 to test compound EC50 for activation of Kir6.2/SUR1 (unknown origin) channel opening
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of Kir6.2/SUR1 (unknown origin) channel opening
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of human Kir6.2/SUR1 channel outward current expressed in HEK293 cells at -70 mV holding potential by EPC9 patch-clamp amplifier based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells assessed as maximal efficacy at 10 uM by thallium flux assay
Assay data:7 Tested
Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells assessed as maximal efficacy at 10 uM by thallium flux assay relative to control
Assay data:27 Tested
Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assay
Assay data:31 Active, 18 Activity ≤ 1 µM, 34 Tested
Inhibition of rat ROMK
thallium-flux assay from US Patent US11632953: "Method for controlling hematophagous or sap-feeding arthropods"
Assay data:7 Active, 9 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Activation of human Kir4.1 expressed in HEK293T cells at 10 uM by patch clamp electrophysiology method
Activation of Kir6.2 channel (unknown origin) by thallium flux assay
Inhibition of ROMK (unknown origin) by Thallium Efflux assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human Kir2.1 expressed in Xenopus laevis oocytes assessed as inhibition of channel current at 10 uM at +40mV holding potential by two-electrode voltage clamp assay
Inhibition of Kir7.1 (unknown origin)
Inhibition of Kir4.1 (unknown origin)
Inhibition of rat Kir1.1 expressed in HEK293 cells by electrophysiology assay
Inhibition of human ROMK expressed in CHO cells by whole cell voltage clamp electrophysiology assay
Assay data:14 Active, 14 Activity ≤ 1 µM, 14 Tested
Electrophysiology Assay from US Patent US10851108: "Substituted bicyclic heterocyclic compounds"
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibitory Activity Assay from US Patent US10759788: "Pharmaceutical uses of pyridine carboxamide derivatives"
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Electrophysiology Assay from US Patent US10723723: "Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors"
Assay data:30 Active, 1 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 30 Tested
Thallium Flux Assay from US Patent US10723723: "Substituted bicycle heterocyclic derivatives useful as ROMK channel inhibitors"
Assay data:171 Active, 2 Activity ≤ 1 nM, 161 Activity ≤ 1 µM, 172 Tested
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