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Inhibition of alpha2beta1 integrin-mediated cell adhesion to type 1 collagen in human platelets incubated for 30 mins in presence of ADP by microplate reader analysis
Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to integrin alpha5beta1 (unknown origin) assessed as inhibition of integrin and fibronectin interaction
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antagonist activity against human integrin alphaVbeta3 expressed in CHO-K1 cells measured after 4 hrs by Cell adhesion assay
Assay data:3 Active, 3 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Solid Phase Integrin αvβ1 Binding Assay from US Patent US20230365556: "N-ACYL AMINO ACID COMPOUNDS AND METHODS OF USE"
Assay data:20 Active, 23 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Solid Phase Integrin alphaVbeta6 Binding Assay from US Patent US20230293519: "INTEGRIN INHIBITORS AND USES THEREOF IN COMBINATION WITH OTHER AGENTS"
Assay data:118 Active, 137 Activity ≤ 1 µM, 137 Tested
Inhibition of Integrin-Ligand Interaction by Reference Inhibitors from US Patent US11685738: "Fluorinated tetrahydronaphthyridinyl nonanoic acid derivatives and uses thereof"
Assay data:14 Active, 1 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
Solid Phase Integrin alphavbeta6 Binding Assay from US Patent US11634418: "Amino acid compounds and methods of use"
Assay data:137 Active, 154 Activity ≤ 1 µM, 155 Tested
Solid Phase Integrin alphavbeta6 Binding Assay from US Patent US11560376: "Amino acid compounds and methods of use"
Assay data:125 Active, 145 Activity ≤ 1 µM, 145 Tested
Solid Phase Integrin alphaVbeta6 Binding Assay from US Patent US20230271960: "AMINO ACID COMPOUNDS AND METHODS OF USE"
Assay data:124 Active, 144 Activity ≤ 1 µM, 144 Tested
Cell Adhesion Assay from US Patent US11530180: "Alpha-5 beta-1 inhibitors"
Assay data:29 Active, 25 Activity ≤ 1 µM, 30 Tested
Inhibition of human recombinant integrin alpha5beta1 incubated for 1 hr by ELISA assay
Assay data:8 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human recombinant integrin alphavbeta3 incubated for 1 hr by ELISA assay
Assay data:1 Active, 8 Tested
Inhibition of human recombinant integrin alphavbeta6 incubated for 1 hr by ELISA assay
Assay data:2 Active, 8 Tested
Antagonist activity at human alphaVbeta3 Integrin assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant human alphavbeta6 integrin incubated for 2 hrs by microplate reader assay
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of alpha5beta1 integrin receptor expressed on human surface of adipose tissue-derived stem cells
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of alphavbeta5 integrin receptor-mediated cell adhesion to vitronectin in human HT-29 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 4 Tested
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human HEK293 cells
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to fibrinogen in human SK-OV-3 cells expressing alphavbeta5 integrin receptor
Inhibition of alphavbeta3 integrin receptor-mediated cell adhesion to vitronectin in human A549 cells preincubated for 30 mins followed by VN substrate addition and measured after 1 hr by crystal violet based staining method
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
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