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SIK2 Enzymatic Assay from US Patent US20240174662: "SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
SIK2 Enzymatic Assay High Version 2 (High ATP) from US Patent US20240174662: "SMALL MOLECULE INHIBITORS OF SALT INDUCIBLE KINASES"
Assay data:483 Active, 47 Activity ≤ 1 nM, 475 Activity ≤ 1 µM, 485 Tested
Enzyme Assay: Pan SIK MS IC50 Assay from US Patent US20240124450: "Novel SIK Inhibitors"
Assay data:43 Active, 33 Activity ≤ 1 nM, 43 Activity ≤ 1 µM, 43 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of SIK2 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
In Vitro SIK2 Kinase Assay from US Patent US20240025892: "SALT INDUCIBLE KINASE INHIBITORS"
Assay data:66 Active, 5 Activity ≤ 1 nM, 63 Activity ≤ 1 µM, 66 Tested
Inhibition of SIK; Abl and Src Kinases by Other Kinase Inhibitor from US Patent US20230348453: "HALOGENATED-HETEROARYL AND OTHER HETEROCYCLIC KINASE INHIBITORS, AND USES THEREOF"
Assay data:29 Active, 29 Activity ≤ 1 µM, 29 Tested
SIK2 Kinase Activity Assay from US Patent US11725011: "Bicyclic urea kinase inhibitors and uses thereof"
Selectivity interaction (NanoBRET assay (HEK293T cells)) EUB0000321b SIK2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Kinase panel (activity or binding assay)) EUB0000674a SIK1
Assay data:1 Tested
Inhibition of GST-tagged human SIK2 autophosphorylation at 5 nM measured after 30 mins in presence of [gamma33P]ATP by Western blot analysis
Inhibition of GST-tagged human SIK2 autophosphorylation measured after 30 mins in presence of [gamma33P]ATP by Western blot analysis
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of full length N-terminal nanoLuc-tagged human SIK1 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of tracer K10 by NanoBRET assay
Inhibition of human SIK1 by radiometric PanQinase activity assay
Inhibition of human SIK3 by radiometric PanQinase activity assay
Inhibition of human SIK2 by radiometric PanQinase activity assay
Inhibition of human SIK1 at 1 uM by radiometric PanQinase activity assay relative to control (Rvb=50%)
Inhibition of human SIK3 at 1 uM by radiometric PanQinase activity assay relative to control (Rvb=50%)
Inhibition of human SIK2 at 1 uM by radiometric PanQinase activity assay relative to control (Rvb=50%)
Inhibition of full length N-terminal nanoLuc-tagged human SIK3 expressed in HEK293 cells using NanoBRET NanoGlo substrate incubated for 2 hrs in presence of tracer K10 by NanoBRET assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 14 Tested
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