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Summary
ATR Enzyme Assay from US Patent US20240025899: "TRIHETEROCYCLIC DERIVATIVE, AND PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF"
Assay data:11 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
ATR Inhibition Assay from US Patent US20230295166: "ATR INHIBITORS AND USES THEREOF"
Assay data:45 Active, 47 Activity ≤ 1 µM, 47 Tested
Assay of ATR Kinase Activity from US Patent US20230271968: "PYRAZOLOPYRIMIDINE COMPOUND USED AS ATR KINASE INHIBITOR"
Assay data:24 Active, 24 Activity ≤ 1 µM, 24 Tested
ATR Inhibition Assay from US Patent US20230271963: "COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE"
Assay data:517 Active, 33 Activity ≤ 1 µM, 549 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Binding Assay ATR (tracer B) from US Patent US11529356: "2-(morpholin-4-yl)-1,7-naphthyridines"
Assay data:55 Active, 53 Activity ≤ 1 µM, 55 Tested
Binding Assay ATR (tracer A) from US Patent US11529356: "2-(morpholin-4-yl)-1,7-naphthyridines"
Assay data:430 Active, 415 Activity ≤ 1 µM, 431 Tested
Inhibition of ATR (unknown origin) assessed as residual activity at 1 uM relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ATR signalling in ATM-deficient human LoVo cells assessed as change in expression of Chk1 at up to 3 uM incubated for 1 hr followed by hydroxyurea addition measured after 4 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of ATR signalling in ATM-deficient human LoVo cells assessed as change in expression of ATR at up to 3 uM incubated for 1 hr followed by hydroxyurea addition measured after 4 hrs by Western blot analysis
Inhibition of ATR signalling in ATM-deficient human LoVo cells assessed as inhibition of Chk1 phosphorylation incubated for 1 hr followed by hydroxyurea addition measured after 4 hrs by Western blot analysis
Assay data:1 Tested
Inhibition of ATR signalling in ATM-deficient human LoVo cells assessed as inhibition of ATR phosphorylation incubated for 1 hr followed by hydroxyurea addition measured after 4 hrs by Western blot analysis
Inhibition of human recombinant full length ATR using GST-cMyc-p53 as substrate incubated for 40 mins in presence of ATP by HTRF assay
Assay data:30 Active, 23 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of ATR in human A2780 cells assessed as induction of DNA damage incubated for 3 days by DAPI staining based immunofluorescence analysis
Inhibition of ATR in HU-treated human A2780 cells assessed as inhibition of Chk1 phosphorylation at Ser345 residue by Western blot assay
Inhibition of ATR in HU-treated human A2780 cells assessed as inhibition of ATR phosphorylation by Western blot assay
Inhibition of ATR in human HT-29 cells assessed as reduction in CHK1 autophosphorylation at S345 residue
Inhibition of ATR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of ATR (unknown origin)-driven CHK1 phosphorylation
Binding affinity to ATR (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
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