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Nitric Oxide Synthetase, Inducible (iNOS) Eurofins Panlabs panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of iNOS (unknown origin)
Assay data:5 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of iNOS expression in LPS-induced mouse RAW264.7 cells
Assay data:3 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human iNOS using L-arginine as substrate assessed as reduction in NO production in the presence of NADPH by NO-hemoglobin capture assay
Assay data:6 Active, 1 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant iNOS (unknown origin) assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate at 10 uM by Enzymatic NOS activity assay
Assay data:10 Active, 10 Tested
Time dependent inhibition of human iNOS at 50 to 800 nM
Binding affinity to recombinant human iNOS assessed as dissociation constant by surface plasmon resonance assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to iNOS in mouse BV-2 cells assessed as thermal stability at 1 uM measured after 3 hr by cellular ITDRF-CETSA
Inhibition of human iNOS assessed as reduction in L-[3H]-citrulline level using L-[3H]-arginine as substrate incubated for 1 hr
Assay data:22 Active, 22 Activity ≤ 1 µM, 22 Tested
Nitric Oxide Suppression Assay from US Patent US11059792: "Imidazolyl tricyclic enones as antioxidant inflammation modulators"
Assay data:27 Active, 27 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Inhibition Assay from US Patent US10759791: "Mammalian and bacterial nitric oxide synthase inhibitors"
Assay data:24 Active, 21 Activity ≤ 1 µM, 24 Tested
Inhibition Assay from US Patent US9242957: "Thiophene-2-carboximidamide based selective neuronal nitric oxide inhibitors"
Assay data:24 Active, 23 Activity ≤ 1 µM, 24 Tested
Inhibition Assay from US Patent US9212144: "2-aminoquinoline-based compounds for potent and selective neuronal nitric oxide synthase inhibition"
Assay data:13 Active, 12 Activity ≤ 1 µM, 16 Tested
Enzyme Inhibition Assay from US Patent US9090589: "Specific nNOS inhibitors for the therapy and prevention of human melanoma"
Assay data:8 Active, 8 Activity ≤ 1 µM, 9 Tested
iNOS Activity Assay from Article 10.1111/cbdd.12575: "Re(I) and Tc(I) complexes for targeting nitric oxide synthase: influence of the chelator in the affinity for the enzyme."
Assay data:1 Active, 6 Tested
Hemoglobin Assay from Article 10.1021/acs.biochem.5b00135: "Mechanistic studies of inactivation of inducible nitric oxide synthase by amidines."
Assay data:4 Active, 1 Activity ≤ 1 µM, 8 Tested
In Vitro Enzyme Assay from US Patent US8927730: "Intramolecular hydrogen-bonded nitric oxide synthase inhibitors"
Assay data:8 Active, 7 Activity ≤ 1 µM, 8 Tested
Spectral Binding Assay from Article 10.1021/bi500561h: "The mobility of a conserved tyrosine residue controls isoform-dependent enzyme-inhibitor interactions in nitric oxide synthases."
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Enzyme Assay from US Patent US8618286: "Benzoxazines, benzothiazines, and related compounds having NOS inhibitory activity"
Assay data:4 Active, 29 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Enzyme Assay from US Patent US8586620: "Substituted indole compounds having NOS inhibitory activity"
Assay data:49 Active, 18 Activity ≤ 1 µM, 52 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
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