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Inhibition of VPS34 (unknown origin)
Assay data:28 Active, 1 Activity ≤ 1 nM, 33 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PIK3C3 (unknown origin) assessed as dissociation constant
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to Vps34 (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Induction of VPS34 degradation in HEK293 cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Induction of VPS34 degradation in HEK293 cells assessed as maximum degradation at 300 nM after 48 hrs relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Induction of VPS34 degradation in HEK293 cells assessed as maximum degradation after 30 mins relative to control
Vps34 Biochemical Assay from US Patent US11780858: "Pyridinamine-pyridone and pyrimidinamine-pyridone compounds"
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PI3K-Alpha kinase (PIK3CA) activity, wild-type and H1047R mutant and determining IC50 values for inhibitors from US Patent US11649227: "Allosteric chromenone inhibitors of phosphoinositide 3-kinase (PI3K) for the treatment of disease"
Assay data:92 Active, 74 Activity ≤ 1 µM, 98 Tested
Vps34 Biochemical Assay from US Patent US11633403: "6-aryl-4-morpholin-1-ylpyridone compounds useful for the treatment of cancer and diabetes"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Vps34 Biochemical Assay from US Patent US11560374: "Morpholinylpyridone compounds"
Biochemical Assay from US Patent US11498919: "Azaindolylpyridone and diazaindolylpyridone compounds"
Assay data:26 Active, 26 Activity ≤ 1 µM, 26 Tested
Selectivity interaction (SelectScreen panel (Invitrogen)) EUB0000685a PIK3C3
SummaryRelated BioAssays by Target
Selectivity interaction (Enzymatic assay) EUB0000685a PIK3C3
Affinity Biochemical interaction (Radioactive liposome kinase assay) EUB0000631a PIK3C3
Affinity Phenotypic Cellular interaction (Inhibition of PtdIns(3)P levels (at endosomes probed by suppression of endosomal localization of GFP?2 FYVEHrs; U2OS cells)) EUB0000631a PIK3C3
Inhibition of human wild type N-terminal GST tagged VPS34 (1 to 887 end) expressed in baculovirus infected Sf21 insect cells using PI and Phosphatidylserine as substrate preincubated with compound for 20 mins followed by substrate addition measured after 90 mins in presence of ATP by ADP-Glo kinase based luminescence assay
Assay data:24 Active, 23 Activity ≤ 1 µM, 24 Tested
Inhibition of VPS34 (unknown origin) at 10 uM relative to control
Assay data:4 Tested
VPS34 DiscoveRx kinase panel
Inhibition of PIK3C3 (unknown origin) assessed as reduction in substrate phosphorylation by FRET Adapta assay
VPS34 ADP-Glo kinase assay from WIPO Patent WO2022093820: "SUBSTITUTED MORPHOLINE COMPOUNDS"
Assay data:47 Active, 35 Activity ≤ 1 µM, 68 Tested
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