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Inhibition of human WDR5 WIN site expressed in Escherichia coli
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Enzyme assay of inhibition against MLL1-WDR5 protein-protein interactions from US Patent US20230286948: "HALOALKYLPYRIDYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR"
Assay data:21 Active, 10 Activity ≤ 1 µM, 56 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Enzyme Assay of Inhibition Against MLL1-WDR5 Protein-Protein Interactions from US Patent US20230286925: "PHENYL TRIAZOLE MLL1-WDR5 PROTEIN-PROTEIN INTERACTION INHIBITOR"
Assay data:33 Active, 32 Activity ≤ 1 µM, 33 Tested
Selectivity interaction (Reader proteins panel (DSF assay)) EUB0000034d WDR5
Assay data:1 Tested
SummaryRelated BioAssays by Target
Selectivity interaction (Methyl-Lysine/Arginine panel (DSF assay)) EUB0000211b WDR5
Selectivity interaction (ITC) EUB0000211b WDR5
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity Biochemical interaction (Biacore) EUB0000211b WDR5
Affinity Phenotypic Cellular interaction (Western Blot (effect on WDR5-MLL interaction in HEK293 cells)) EUB0000211b WDR5
Competitive binding affinity to N-terminal 6xHis-SUMO-tagged human WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold (DE3) cells assessed as inhibition constant using 10-mer-Thr-FAM peptide as substrate incubated for 1 hr by Lantha Screen based TR-FRET assay
Assay data:36 Active, 34 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 39 Tested
Inhibition of N-terminal 6xHis-SUMO-tagged human WDR5 (22 to 334 residues) expressed in Escherichia coli BL21-Gold (DE3) cells assessed as inhibition constant incubated for 1 hr by TR-FRET assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of MLL1-WDR5 (unknown origin) interaction using 10mer-Thr-FAM as substrate by fluorescence polarization based competitive binding assay
Binding affinity to WDR5 (unknown origin) using 10mer-Thr-FAM as substrate incubated for 30 mins by fluorescence polarization based competitive binding assay
Binding affinity to poly histidine tagged-human WDR5 (1 to 334 residues) expressed in Escherichia coli BL21 (DE3)-V2R-pRARE2 assessed as dissociation constant by surface plasmon resonance assay
Inhibition of 5- FAM labeled tracer binding to N-terminal His6-SUMO-tagged WDR5 (24 to 334 residues) (unknown origin) expressed in Escherichia coli Rosetta 2 (DE3) cells incubated for 3 hrs by fluorescence polarization based competitive binding assay
Binding affinity to WDR5 (unknown origin) WIN site using 10mer-Thr-FAM probe incubated for 2 hrs by fluorescence polarization assay
Binding affinity to WDR5 (unknown origin) by isothermal titration calorimetry
Binding affinity to human WDR5 by isothermal titration calorimetry
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Displacement of GSARAEVHLRKS from human WDR5 by fluorescence polarization assay
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to WDR5 (unknown origin) fluorescence polarization assay
Assay data:8 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
Binding affinity to N-terminal His-tagged and C-terminal Avi-tagged full length human WDR5 WIN site expressed in Escherichia coli measured upto 600 sec by Surface plasmon resonance assay
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