Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19636101.

Bioluminescence Resonance Energy Transfer (BRET) Assay from US Patent US20240132519: "NRF2-ACTIVATING COMPOUND"

Source:: BindingDB

Protein Targets:: Kelch-like ECH-associated protein 1; ...
Total:: 2

Assay data:35 Active, 24 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 35 Tested

AID:: 1963610

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19563222.

Invivo inhibition of Nrf2-Keap1 Kelch domain protein-protein interaction in po dosed Wistar rat kidney assessed as increase in HO-1 protein level by measuring fold change at 30 mg/kg incubated for 6 hrs by ELISA assay relative to control

Source:: ChEMBL

Protein Targets:: Kelch-like ECH-associated protein 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1956322

Summary PubMed Citation Related BioAssays by Target

Select item 19563213.

Invivo inhibition of Nrf2-Keap1 Kelch domain protein-protein interaction in po dosed Wistar rat kidney assessed as increase in HO-1 protein level incubated for 6 hrs by ELISA assay

Source:: ChEMBL

Protein Targets:: Kelch-like ECH-associated protein 1; ...
Total:: 2

Assay data:1 Tested

AID:: 1956321

Summary PubMed Citation Related BioAssays by Target

Select item 19563114.

Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in entropy by isothermal titration calorimetry assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:3 Tested

AID:: 1956311

Summary PubMed Citation Related BioAssays by Target

Select item 19563105.

Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in enthalpy by isothermal titration calorimetry assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:3 Tested

AID:: 1956310

Summary PubMed Citation Related BioAssays by Target

Select item 19563096.

Binding affinity to Keap1 Kelch domain (unknown origin) assessed as change in free energy by isothermal titration calorimetry assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:3 Tested

AID:: 1956309

Summary PubMed Citation Related BioAssays by Target

Select item 19563027.

Inhibition of Nrf2-Keap1 Kelch domain (unknown origin) protein-protein interaction in presence of biotin labeled 16mer ETGE peptide AFFAQLQLDEETGEFL

Source:: ChEMBL

Protein Targets:: Kelch-like ECH-associated protein 1; ...
Total:: 2

Assay data:5 Active, 2 Activity ≤ 1 µM, 21 Tested

AID:: 1956302

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19309628.

Inhibition of KEAP1/p62 (unknown origin) protein-protein interaction

Source:: ChEMBL

Protein Targets:: Kelch-like ECH-associated protein 1; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1930962

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19309619.

Inhibition of KEAP1/Nrf2 (unknown origin) protein-protein interaction

Source:: ChEMBL

Protein Targets:: Kelch-like ECH-associated protein 1; ...
Total:: 2

Assay data:1 Active, 1 Tested

AID:: 1930961

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192738310.

Binding affinity to human KEAP1 by fluorescence anisotropy assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:2 Active, 2 Tested

AID:: 1927383

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192738211.

Binding affinity to human KEAP1 by fluorescence based assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:1 Active, 1 Tested

AID:: 1927382

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192738112.

Binding affinity to human KEAP1

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:1 Active, 1 Tested

AID:: 1927381

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192738013.

Inhibition of human Keap1-Nrf2 protein-protein interaction

Source:: ChEMBL

Protein Targets:: Kelch-like ECH-associated protein 1; ...
Total:: 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1927380

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192737914.

Binding affinity to human KEAP1 incubated for 1 hr by absorbance based analysis

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1927379

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192737815.

Binding affinity to human KEAP1 by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1927378

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192737716.

Inhibition of human Keap1-Nrf2 protein-protein interaction by fluorescence polarization assay

Source:: ChEMBL

Protein Targets:: Kelch-like ECH-associated protein 1; ...
Total:: 2

Assay data:12 Active, 10 Activity ≤ 1 µM, 14 Tested

AID:: 1927377

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192737617.

Binding affinity to human KEAP1 by isothermal titration calorimetric assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1927376

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192737518.

Inhibition of human KEAP1 by fluorescence polarization assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1927375

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192737419.

Binding affinity to human KEAP1 Kelch domain (residues Ala321-Thr609) expressed in Escherichia coli BL21(DE3) cells assessed as dissociation constant by isothermal titration calorimetric analysis

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:1 Active, 1 Tested

AID:: 1927374

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 192737320.

Binding affinity to human KEAP1 Kelch domain (residues Ala321-Thr609) expressed in Escherichia coli BL21(DE3) cells assessed as dissociation constant by SPR direct binding assay

Source:: ChEMBL

Protein Target:: Kelch-like ECH-associated protein 1

Assay data:1 Tested

AID:: 1927373

Summary PubMed Citation Related BioAssays by Target

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Proteins (13)
BioAssays with protein sequences specified as targets

BioActivity

Chemical Probes (1)
BioAssays with compounds reported as validated chemical probes

Active Compounds (333)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (8)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (127)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (173)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (12)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (569)
BioAssays extracted from the literature
NIH MLP (12)
BioAssays deposited by the NIH Molecular Libraries Program

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Related BioAssays, by Target Similarity (List) for PubChem BioAss... (581)
Related BioAssays, by Target Similarity (List) for PubChem BioAssay (Select 1930962)
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PubChem BioAssay
Rattus norvegicus strain BN/NHsdMcwi chromosome 19, GRCr8, whole genome shotgun ...
Rattus norvegicus strain BN/NHsdMcwi chromosome 19, GRCr8, whole genome shotgun sequence
gi|2671914586|gnl|ASM:GCF_036323745 9|ref|NC_086037.1||gpp|GPC_000020862.1||gnl|NCBI_GENOMES|157508

Nucleotide
NOTCH antagonist SAHM1 effect on T-ALL cell lines
NOTCH antagonist SAHM1 effect on T-ALL cell lines
Accession: GDS3717

GEO DataSets
Related DataSets for GEO Profiles (Select 65681575) (1)
GEO DataSets

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