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MNK Biochemical Enzymatic Assay from US Patent US20240092799: "MNK INHIBITORS"
Assay data:156 Active, 169 Activity ≤ 1 µM, 169 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of MKNK2 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MNK1 (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human partial length wild type Mnk2 (G63/S388) expressed in mammalian system at 1 uM by KINOMEscan analysis relative to control
Binding affinity MNK2 (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of MNK2 (unknown origin) at 1 uM incubated for 60 mins by HTRF assay relative to control
Inhibition of MNK1 (unknown origin) at 1 uM incubated for 60 mins by HTRF assay relative to control
Inhibition of MNK2 (unknown origin)
Inhibition of MNK2 (unknown origin) at 3 uM in presence of ATP by kinase assay
Inhibition of MNK1 (unknown origin) at 3 uM in presence of ATP by kinase assay
Inhibition of MNK2 (unknown origin) incubated for 60 mins using CREB as substrate in presence of ATP by LANCE Ultra kinase assay
Assay data:12 Active, 12 Activity ≤ 1 µM, 12 Tested
Inhibition of MNK1 (unknown origin) incubated for 60 mins using CREB as substrate in presence of ATP by LANCE Ultra kinase assay
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000637a MKNK2
Selectivity interaction (Ambit kinome screening platform (Ambit phage-based competition binding assay)) EUB0000624a MKNK2
SummaryRelated BioAssays by Target
Selectivity interaction (Upstate Kinase Profiler service (Millipore)) EUB0000056c MKNK2
Inhibition of human MNK1/MNK2 at 10 uM using S6 peptide as substrate in presence of [gamma-33P]-ATP incubated for 60 mins by radiometric scintillation counting method
Assay data:45 Tested
Inhibition of MNK1 in human MDA-MB-231 cells assessed as inhibition of eIF4E phosphorylation at 10 uM by Western blot analysis
Activation of MNK1 in human MDA-MB-231 cells assessed as increase in ERK expression at 25 to 100 uM incubated for 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of MNK1 in human MDA-MB-231 cells assessed as effect on p38 expression at 25 to 100 uM incubated for 24 hrs by Western blot analysis
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