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Binding affinity to HSP90 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to full length HSP90 (unknown origin) expressed in Escherichia coli BL21(DE3) cells at 20 uM by NMR STD assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HSP90 in human HL-60 cells assessed as decrease in CDK4 protein expression incubated for 24 hrs by western blot analysis
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HSP90 in human HL-60 cells assessed as increase in HSP27 protein expression incubated for 24 hrs by western blot analysis
Inhibition of HSP90 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of HSP90alpha in human NCI-H522 cells assessed as decrease in CDK4 level at 10 to 80 uM incubated for 24 hrs by Western blot analysis
Assay data:2 Active, 2 Tested
Inhibition of HSP90alpha in human SK-OV-3 cells assessed as decrease in CDK4 level at 10 to 80 uM incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human SK-OV-3 cells assessed as decrease in p-Src level at 10 to 80 uM incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human SK-OV-3 cells assessed as decrease in p-Akt level at 10 to 80 uM incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human SK-OV-3 cells assessed as decrease in c-Src protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human SK-OV-3 cells assessed as decrease in survivin protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human SK-OV-3 cells assessed as decrease in Akt protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human SK-OV-3 cells assessed as decrease in Raf-1 protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human SK-OV-3 cells assessed as decrease in Her2 protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human NCI-H522 cells assessed as decrease in c-Src protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human NCI-H522 cells assessed as decrease in survivin protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human NCI-H522 cells assessed as decrease in Akt protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human NCI-H522 cells assessed as decrease in Raf-1 protein level incubated for 24 hrs by Western blot analysis
Inhibition of HSP90alpha in human NCI-H522 cells assessed as decrease in Her2 protein level incubated for 24 hrs by Western blot analysis
Binding affinity to HSP90beta (unknown origin)
Assay data:24 Active, 5 Activity ≤ 1 µM, 42 Tested
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