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Inhibition of LAR (unknown origin) assessed as inhibition constant
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of LAR (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of rat recombinant LAR expressed in Escherichia coli assessed as inhibition constant using pNPP as substrate incubated for 5 mins by liquid scintillation counter analysis
Assay data:1 Tested
Inhibition of recombinant LAR (unknown origin)
Assay data:5 Tested
Inhibition of PTPsigma (unknown origin)
Assay data:3 Tested
Inhibition of LAR(unknown origin)
Inhibition of human LAR
Assay data:10 Tested
Enzyme Kinetic Assay from US Patent US9340574: "Inhibitors of protein tyrosine phosphatases"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PTP pNPP Assay from US Patent US9217012: "Inhibitors of protein tyrosine phosphatases"
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition Assay from US Patent US8987474: "Inhibition of Shp2/PTPN11 protein tyrosine phosphatase by NSC-87877, NSC-117199 and their analogs"
Assay data:9 Active, 2 Activity ≤ 1 µM, 124 Tested
Inhibitory Assay from Article 10.1002/cbdv.201000242: "Synthesis of (glycopyranosyl-triazolyl)-purines and their inhibitory activities against protein tyrosine phosphatase 1B (PTP1B)."
Assay data:5 Active, 13 Tested
pNPP assay from Article 10.1016/j.bmcl.2014.03.015: "Synthesis and biological evaluation of novel bis-aromatic amides as novel PTP1B inhibitors."
Assay data:9 Active, 21 Tested
Inhibitor Assay from Article 10.1016/j.carres.2010.10.023: "Preparation of triazole-linked glycosylated ??????-ketocarboxylic acid derivatives as new PTP1B inhibitors."
Assay data:2 Active, 11 Tested
PTP Assay from Article 10.1002/cbic.200600287: "Cellular inhibition of protein tyrosine phosphatase 1B by uncharged thioxothiazolidinone derivatives."
Assay data:7 Active, 16 Tested
Determination of Inhibitor Ki from Article 10.1021/ja0727520: "Fragment-based substrate activity screening method for the identification of potent inhibitors of the Mycobacterium tuberculosis phosphatase PtpB."
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of His-tagged PTPsigma (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for 5 to 10 mins by microplate reader based spectrophotometric analysis
Assay data:9 Tested
Inhibition of His-tagged LAR (unknown origin) expressed in Escherichia coli BL21 cells using para-nitrophenyl phosphate as substrate incubated for 5 to 10 mins by microplate reader based spectrophotometric analysis
Inhibition of PTPRF (unknown origin) assessed as change in enzyme activity at 150 uM using tyrosine phosphopeptide-2 substrate incubated for 15 mins relative to control
SummaryRelated BioAssays by Target
Inhibition of PTPRS (unknown origin) assessed as change in enzyme activity at 150 uM using PNPP substrate incubated for 15 mins relative to control
Ratio of Kinact to Ki for LAR (unknown origin) using DiFMUP as substrate incubated for 15 to 120 mins followed by substrate addition at pH 6.5 by standard phosphatase assay based fluorescence analysis
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