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Phosphatase (PTPase) Assay from US Patent US20240199525: "SHP2-Targeting Small Molecules For Use As Anti-Cancer Agents"
Assay data:6 Active, 2 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of PTP1B (unknown origin) by DAS-ELISA
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PTP1B (unknown origin) at 10 micromol/L by DAS-ELISA
Assay data:29 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of PTP1B (unknown origin) using pNPP as substrate preincubated for 10 mins followed by substrate addition and measured every 30 sec for 10 mins by microplate photometer analysis
Assay data:5 Tested
Inhibition of human recombinant GST-tagged PTP1B (1 to 321 residues) expressed in Escherichia coli using pNPP as substrate preincubated for 10 mins followed by substrate addition and measured after 30 mins by microplate reader assay
Assay data:1 Tested
Inhibition of human recombinant PTP1B using pNPP as substrate incubated for 40 min
Inhibition of human PTP1B using pNPP as substrate incubated for 30 min by UV-Visible spectrophotometer assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of PTP1B (unknown origin) using DiFMUP as substrate incubated for 30 min by fluorescence based microplate reader assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of human PTP1B using pNPP as substrate incubated for 30 min by microplate reader assay
Inhibition of human recombinant GST-tagged PTP1B (1 to 321 residues) expressed in Escherichia coli using pNPP as substrate by spectrophotometer assay
Inhibition of PTP1B (unknown origin) using pNPP as substrate
Inhibition of human PTP1B (1 to 411 residues) expressed in Escherichia coli BL21 (DE3) using GNGDpYMPMSPKS as phosphopeptide substrate incubated for 30 mins by malachite green reagent assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of human recombinant PTP1B expressed in Escherichia coli BL21 (DE3) using pNPP as substrate by high-throughput screening assay
Inhibition of human PTP1B (1 to 298 residues) expressed in Escherichia coli using FDP as substrate by microplate reader
Inhibition of human PTP1B expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as substrate incubated for 15 min by Michaelis-Menten analysis
Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrate
Assay data:2 Active, 2 Tested
Inhibition of PTP1B (unknown origin) assessed as inhibition constant
Assay data:7 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 8 Tested
Inhibition of human recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate
Inhibition of rat recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate
Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate incubated for 60 min by Michaelis-Menten analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
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