Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19634961.

PI3K-delta Scintillation Proximity Assay from US Patent US11926616: "Aminopyrazine diol compounds as PI3K-γ inhibitors"

Source:: BindingDB

Protein Targets:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform; ...
Total:: 1

Assay data:46 Active, 43 Activity ≤ 1 µM, 46 Tested

AID:: 1963496

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 19558742.

Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate preincubated for 1 hr followed by ATP and substate addition and measured after 1 hr by ADP-glo reagent based assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:2 Active, 5 Tested

AID:: 1955874

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 19525523.

Antagonist activity at PI3Kdelta (unknown origin) using PIP2 as substrate in presence of ATP incubated for 30 to 60 mins by ADP-glo based luminescence assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1952552

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19525504.

Antagonist activity at PI3Kdelta (unknown origin) assessed as inhibition rate at 20 nM using PIP2 as substrate in presence of ATP incubated for 30 to 60 mins by ADP-glo based luminescence assay relative to control

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:29 Tested

AID:: 1952550

Summary PubMed Citation Related BioAssays by Target

Select item 19498395.

Inhibition of PI3Kdelta (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1949839

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19494236.

Inhibition of PI3K-delta (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1949423

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19494177.

Inhibition of human PI3K-delta using PIP2 as substrate in presence of gamma[32P]ATP

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1949417

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19457928.

Inhibition of PI3Kdelta (unknown origin) preincubated for 10 mins followed by ATP addition and measured after 60 mins by ADP-Glo assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Tested

AID:: 1945792

Summary PubMed Citation Related BioAssays by Target

Select item 19431059.

Inhibition of PI3Kdelta (unknown origin) in presence of 75 uM ATP

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1943105

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194309810.

Inhibition of PI3Kdelta (unknown origin) at 0.1 uM relative to control

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Tested

AID:: 1943098

Summary PubMed Citation Related BioAssays by Target

Select item 194061811.

Inhibition of PI3Kdelta (unknown origin) by ADP Glo luminescent assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:12 Active, 1 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 25 Tested

AID:: 1940618

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194003012.

Inhibition of PI3Kdelta (unknown origin) at 1 uM

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1940030

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194002913.

Binding affinity to PI3Kdelta (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Activity ≤ 1 µM, 1 Tested

AID:: 1940029

Summary Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 193487914.

Inhibition of PI3 Kinase p110delta/p85alpha (unknown origin) at 1 uM relative to control

Source:: ChEMBL

Protein Targets:: Phosphatidylinositol 3-kinase regulatory subunit alpha; ...
Total:: 2

Assay data:1 Tested

AID:: 1934879

Summary PubMed Citation Related BioAssays by Target

Select item 193407815.

Inhibition of PI3Kdelta (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested

AID:: 1934078

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192892016.

Inhibition of PI3Kdelta (unknown origin) incubated for 90 mins by [gamma-33P]-ATP based scintillation counting method

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested

AID:: 1928920

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192857117.

Inhibition of human PI3Kdelta assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1928571

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192856318.

Inhibition of PI3Kdelta (unknown origin)

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1928563

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192855819.

Inhibition of C-terminal His-tagged full-length PI3K p110delta (unknown origin) expressed in baculovirus incubated for 120 mins by Kinase-Glo luminescence assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1928558

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 192553120.

Inhibition of PI3Kdelta (unknown origin) using PIP2 as substrate incubated for 1 hr in presence of ATP by ADP-Glo assay

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1925531

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (719)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (128)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (650)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (865)
BioAssays extracted from the literature
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