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IKBKB Invitrogen Lab (UK) kinase screen (BI)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of IKK2 (unknown origin) by Ambit kinase assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of IkappaB phosphorylation in LPS-induced mouse RAW264.7 cells preincubated with compound for 2 hrs followed by LPS stimulation and measured after 6 hrs by Western blot analysis
Inhibition of IKKB (unknown origin)
Assay data:2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Kinase (PDGFRα, PDGFRβ, ABL1 and FLT3) Inhibition Test of Compounds from US Patent US20230312529: "PYRIMIDINE SMALL-MOLECULE COMPOUND AND APPLICATION THEREOF"
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Kinase Activity Assay from US Patent US11691950: "Isoquinoline-steroid conjugates and uses thereof"
Assay data:21 Active, 18 Activity ≤ 1 µM, 21 Tested
Selectivity interaction (Kinase Panel (competition binding assay)) EUB0000589aTFA IKBKB
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (Enzymatic assay) EUB0000624a IKBKB
Affinity Biochemical interaction (Competition binding assay) EUB0000589aTFA IKBKB
Affinity Phenotypic Cellular interaction (Immunoblotting (inhibition of CHUK phosphorylation in THP-1 cells)) EUB0000589aTFA IKBKB
Assay data:1 Active, 1 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of IKKbeta (unknown origin) at 50 nM by Z'LYTE screening method relative to control
Inhibition of recombinant human full length IKKbeta assessed as residual activity at 1 uM using peptide as substrate incubated for 40 mins in presence of [gamma 33P]-ATP by radiometric scintillation counting assay relative to control
Inhibition of human IKKbeta assessed as residual activity at 30 uM relative to control
Inhibition of IKK2 (unknown origin)
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of IkappaB phosphorylation in LPS-stimulated mouse BV-2 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by Western blot analysis
Inhibition of IkappaB activation in LPS-stimulated mouse BV-2 cells pretreated for 1 hr followed by LPS stimulation and measured after 24 hrs by Western blot analysis
Inhibition of IkappaBalpha phosphorylation at Ser176/180 in LPS-induced mouse C8D1A cells at 0.75 to 3 uM pretreated for 4 hrs followed by LPS stimulation measured after 24 hrs by Western blotting analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of IKKalpha/beta phosphorylation at Ser176/180 in LPS-induced mouse C8D1A cells at 0.75 to 3 uM pretreated for 4 hrs followed by LPS stimulation measured after 24 hrs by Western blotting analysis
Covalent modification of N-terminal hexa-his-tagged human recombinant IKKbeta assessed as high molecular weight band formation at 1:10 protein to compound concentration measured after 24 hrs by SDS-PAGE based silver staining analysis
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