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Inhibition Tests on JAK-1, JAK-2 and JAK-3 Kinases from US Patent US11993603: "Preparation for 6-amino-1H-pyrazolo[3,4-d]pyrimidine-based JAK kinase inhibitor and application thereof"
Assay data:28 Active, 11 Activity ≤ 1 nM, 28 Activity ≤ 1 µM, 28 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
JAK2 Activity Inhibitory Assay from US Patent US20240150367: "NITROGEN-CONTAINING SPIRO CYCLIC COMPOUNDS AND PHARMACEUTICAL USE THEREOF"
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
JAK2 Binding Assay from US Patent US20240116892: "HETEROCYCLIC AMIDE AND UREA COMPOUNDS AS JAK2 INHIBITORS"
Assay data:263 Active, 254 Activity ≤ 1 µM, 264 Tested
Radiometric Assay from US Patent US20240140952: "INHIBITORS AND DEGRADERS OF JANUS KINASE 2"
Assay data:15 Active, 9 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Biochemical Kinase Assay Protocol (JAK) from US Patent US20240132525: "BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF"
Assay data:90 Active, 39 Activity ≤ 1 nM, 91 Activity ≤ 1 µM, 91 Tested
JAK2 Z-Lyte Biochemical Assay from US Patent US20240101559: "TRICYCLIC KINASE INHIBITORS AND USES THEREOF"
Assay data:9 Active, 1 Activity ≤ 1 µM, 11 Tested
Biochemical JAK Kinase Assays from US Patent US20240092758: "IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS"
Assay data:392 Active, 381 Activity ≤ 1 nM, 392 Activity ≤ 1 µM, 392 Tested
In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"
Assay data:34 Active, 22 Activity ≤ 1 µM, 34 Tested
NanoBRET assay (JAK2, SGC Frankfurt)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of JAK2 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of JAK2 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of JAK2 (unknown origin)
Assay data:10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of JAK2 (unknown origin) at 1 uM relative to control
Inhibition of JAK2 dependent GM-CSF stimulated STAT3 phosphorylation in human TF-1 cells
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of JAK (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK2 (unknown origin) by Ambit kinase assay
Assay data:4 Tested
Inhibition of GST-fused JAK2 (808 to 1132 residues) (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in presence of ATP by Janus kinase assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
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