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CYP1A2 Inhibition Assay from US Patent US11938127: "Methods and compositions relating to steroid hormone receptor-dependent proliferative disorders"
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of CYP1A2 in human liver microsomes using phenacetin as substrate at 10 uM preincubated for 10 mins followed by NADPH addition and measured after 15 mins by LC-MS/MS analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CYP1A2 (unknown origin)
Assay data:3 Tested
Reversible inhibition of CYP1A2 in human liver microsomes assessed as residual activity at 5 uM using phenacetin as substrate preincubated for 30 mins followed by substrate addition measured after 20 mins by LC-MS/MS analysis relative to control
Assay data:4 Tested
Inhibition of human CYP1A2
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CYP1A2 in human liver microsomes using midazolam as substrate preincubated for 15 mins followed by NADPH addition and measured after 8 mins by LC/MS/MS analysis
Assay data:1 Active, 1 Tested
Induction of CYP1A2 in human hepatocytes
Inhibition of recombinant CYP1A1 (unknown origin) assessed as decrease in EROD activity using 7-ethoxyresorufin as substrate upto 100 uM incubated for 15 mins by resorufin dye based spectrofluorimetry
Assay data:6 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 100 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:11 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 50 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 10 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:8 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 5 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 1 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Assay data:10 Tested
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 0.1 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Inhibition of recombinant CYP1A1 (unknown origin) assessed as residual enzyme activity using 7-ethoxyresorufin as substrate at 0.01 uM incubated for 15 mins by resorufin dye based spectrofluorimetry (Rvb = 100%)
Substrate activity at CYP1A1 in human liver microsomes assessed as metabolite formation at 1 mM preincubated for 10 mins followed by NADPH and CYP1A1 inhibitor, alpha-naphthoflavone addition and measured after 60 mins by LC/ESI/MS-EIC analysis
Assay data:2 Tested
Substrate activity at CYP1A1 in human liver microsomes assessed as metabolite formation at 1 mM preincubated for 10 mins followed by NADPH addition and measured after 60 mins by LC/ESI/MS-EIC analysis
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