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Homogeneous Time-Resolved Fluorescence (HTRF) from US Patent US20240199625: "BICYCLIC HETEROCYCLIC FGFR4 INHIBITOR, PHARMACEUTICAL COMPOSITION AND PREPARATION COMPRISING SAME, AND APPLICATION THEREOF"
Assay data:8 Active, 3 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Kinase Assay from US Patent US20240109865: "INDAZOLE COMPOUNDS AS KINASE INHIBITORS"
Assay data:359 Active, 363 Activity ≤ 1 µM, 363 Tested
FGFR3 SGC Tm panel (DSF)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of FGFR3 (unknown origin) at 10 uM by biochemical hotspot kinase assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of FGFR (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of FGFR4 in human Hep3B cells assessed as reduction in ERK phosphorylation by Western blot analysis
Inhibition of FGFR4 in human Hep3B cells assessed as reduction in AKT phosphorylation by Western blot analysis
Inhibition of FGFR4 phosphorylation in human Hep3B cells by Western blot analysis
Inhibition of recombinant His-tagged human FGFR4 (781 to 1338 residues) expressed in insect cells incubated for 1 hr by caliper mobility shift assay
Assay data:9 Active, 9 Activity ≤ 1 µM, 26 Tested
Inhibition of recombinant His-tagged human FGFR4 (781 to 1338 residues) expressed in insect cells at 1 uM incubated for 1 hr by caliper mobility shift assay relative to control
Assay data:26 Tested
Inhibition of FGFR3 (unknown origin) at 1 uM relative to control
Inhibition of FGFR4 (unknown origin) at 1 uM relative to control
Inhibition of FGFR3 phosphorylation in mouse BaF3 cells incubated for 2 hrs
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of recombinant human FGFR4 (460 to 802 residues) using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay
Inhibition of recombinant N-terminal His-Avi-tag human FGFR3 (447 to 761 residues) expressed in Sf9 infected baculovirus expression system using biotin-EQEDEPEGDYFEWLE-amide as substrate preincubated for 5 to 10 mins followed by substrate addition and measured after 1 hr in presence of ATP by HTRF assay
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Inhibition of wild type human partial length FGFR3 (R442 to S771 residues) expressed in bacterial expression system at 100 uM by Kinome scan method relative to control
Inhibition of human FGFR4
Inhibition of human FGFR3
Inhibition of human recombinant GST-fused FGFR3 expressed in baculovirus expression system using poly-Glu-Tyr (4:1) as substrate measured after 10 mins in presence of gamma-[33P]-ATP by scintillation counting analysis
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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