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Potency index, ratio of diazoxide EC50 to test compound EC50 for activation of Kir6.2/SUR1 (unknown origin) channel opening
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Activation of Kir6.2/SUR1 (unknown origin) channel opening
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of human Kir6.2/SUR1 channel outward current expressed in HEK293 cells at -70 mV holding potential by EPC9 patch-clamp amplifier based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells assessed as maximal efficacy at 10 uM by thallium flux assay
Assay data:7 Tested
Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells assessed as maximal efficacy at 10 uM by thallium flux assay relative to control
Assay data:27 Tested
Activation of Kir6.2/SUR1 (unknown origin) channel opening expressed in human T-REx-293 cells by thallium flux assay
Assay data:31 Active, 18 Activity ≤ 1 µM, 34 Tested
thallium-flux assay from US Patent US11632953: "Method for controlling hematophagous or sap-feeding arthropods"
Assay data:7 Active, 9 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Activation of Kir6.2 channel (unknown origin) by thallium flux assay
KATP channel Eurofins-Cerep binding assay
Assay data:2 Tested
SummaryRelated BioAssays by Target
KATP channel CEREP ligand profiling
Rat Kir6.2 (Inwardly rectifying potassium channels)
Assay data:4 Active, 4 Tested
Mouse Kir6.1 (Inwardly rectifying potassium channels)
Assay data:7 Active, 7 Tested
Human Kir6.2 (Inwardly rectifying potassium channels)
Assay data:3 Active, 3 Tested
Human Kir6.1 (Inwardly rectifying potassium channels)
Mouse Kir6.2 (Inwardly rectifying potassium channels)
Assay data:6 Active, 6 Tested
Human ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC subfamily)
Assay data:2 Active, 2 Tested
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