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Inhibition of sigma 2 receptor (unknown origin)
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
SummaryRelated BioAssays by Target
Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes assessed as inhibition constant presence of haloperidol by scintillation counting analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Displacement of [3H]DTG from sigma 2 receptor in rat liver membranes assessed as inhibition constant presence of dextrallorphan
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of haloperidol measured for 120 mins by scintillation counting analysis
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant in presence of (+)-SKF10047 by radioligand binding assay
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Tested
Displacement of [3H]DTG from sigma 2 receptor (unknown origin) assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by radioligand binding assay
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as displacement of compound by measuring inhibition constant of 2-(3-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)propyl)-5-methoxy-3,4-dihydroisoquinolin-1(2H)-one incubated for 120 mins by saturation binding assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as displacement of compound by measuring inhibition constant of DTG incubated for 120 mins by saturation binding assay
Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to sigma 2 receptor in human MCF7 cells assessed as increase in fluorescent intensity pretreated with (+)-pentazocine for 60 mins followed by compound addition incubated for 45 mins by flow cytometric analysis
Assay data:1 Tested
Displacement of [3H]DTG from sigma 2 receptor in Wistar Han rat liver membrane assessed as inhibition constant incubated for 120 mins
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
Displacement of [3H]RHM-1 from sigma 2 receptor in Wistar Han rat liver membrane assessed as inhibition constant by competitive binding assay
Displacement of [3H]DTG from sigma 2 receptor in Wistar Han rat liver membrane assessed as inhibition constant by competitive binding assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to sigma 2 receptor (unknown origin) assessed as inhibition constant
Assay data:4 Active, 1 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested
Displacement of [3H]DTG from sigma-2 receptor in HEK293 cell membrane assessed as inhibition constant
Assay data:20 Active, 20 Activity ≤ 1 µM, 20 Tested
Inhibition of Sigma2 receptor (unknown origin) at 10 uM
Displacement of [3H]DTG from sigma 2 receptor expressed in rat liver membranes assessed as inhibition constant incubated for 120 mins in presence of (+)-SKF10047 by radioligand binding assay
Displacement of [3H]DTG from sigma 2 receptor expressed in rat liver membranes assessed as inhibition constant in presence of (+)-pentazocine by radioligand binding assay
Assay data:10 Active, 9 Activity ≤ 1 µM, 10 Tested
Binding affinity to sigma 2 receptor (unknown origin) expressed in human RT-4 cells
Binding affinity to sigma 2 receptor expressed in rat liver
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