Related BioAssays, by Target Similarity (List) for PubChem BioAssay (S - PubChem BioAssay - NCBI

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Select item 19601061.

Agonist activity at human RORgammat

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960106

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19601052.

Inverse agonist activity at human RORgammat

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960105

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19600963.

Inhibition of human RORgammmat LBD expressed in HEK293T by two-hybrid reporter assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960096

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19600954.

Inhibition of human RORgammmat LBD expressed in HEK293T by one-hybrid reporter assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960095

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19600945.

Inhibition of human RORgammmat LBD expressed in Escherichia coli by FRET co-activator peptide assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960094

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19600936.

Inhibition of human RORgammmat LBD expressed in Escherichia coli by ThermoFluro assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960093

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19600927.

Inhibition of GAL4-RORgammat LBD (unknown origin)

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960092

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19600918.

Inhibition of RORgammat LBD (unknown origin) expressed in Sf21 cells assessed as fluorescence signal by TR-FRET assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960091

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19600909.

Inverse agonist activity at human GAL4-RORgamma DBD expressed in HEK293 cells measured after 24 hrs by ligand binding assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1960090

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196008910.

Inverse agonist activity at GAL4-RORgammat LBD (unknown origin) expressed in HEK293 cells at 1 uM measured after 24 hrs by nuclear receptor assay relative to control

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Tested

AID:: 1960089

Summary PubMed Citation Related BioAssays by Target

Select item 196008411.

Inverse agonist activity at GAL4-RORgammat LBD (unknown origin) expressed in HEK293 cells measured after 18 to 24 hrs by nuclear receptor assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960084

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196008312.

Inhibition of biotinylated human RORgammat by FRET assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960083

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196008013.

Inhibition of human GAL4-fused RORgammat LBD transfected in Escherichia coli BL21(DE3) cell measured after 16 hrs by HTRF assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1960080

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196007214.

Inhibition of RORgammat (unknown origin) by cell based reporter gene assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960072

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196007115.

Inhibition of RORgammat (unknown origin) by binding assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960071

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196007016.

Inhibition of His-tagged human RORgammat LBD in presence of biotin-coactivator peptide SRC1 binding incubated for 1 hr by TR-FRET assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1960070

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196006917.

Antagonist activity at RORgammat LBD (unknown origin) assessed as fluorescent polarization signal measured in presence of fluorescein-labeled LXR agonist T0901317 after 4 hrs by competitive binding assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960069

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196006518.

Inverse agonist activity at His-tagged human RORgammat LBD assessed as inhibition of biotinylated RIP140 co-activator peptide binding incubated for 1 hr by TR-FRET assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960065

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196006019.

Inverse agonist activity at GAL4-tagged RORgammat (unknown origin) expressed in HEK293 cells measured after 18 hrs by luciferase assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960060

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196005720.

Inhibition of RORgamma LBD (unknown origin) incubated for 1 hr by TR-FRET assay

Source:: ChEMBL

Protein Target:: Nuclear receptor ROR-gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1960057

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (22)
BioAssays with protein sequences specified as targets

BioActivity

Chemical Probes (2)
BioAssays with compounds reported as validated chemical probes

Active Compounds (533)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (50)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (474)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (3)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (509)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (3)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (20)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (717)
BioAssays extracted from the literature
NIH MLP (18)
BioAssays deposited by the NIH Molecular Libraries Program
Other (5)
BioAssays deposited by other experimentalists

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Related BioAssays, by Target Similarity (List) for PubChem BioAssay (Select 1960095)
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PubChem BioAssay
Related DataSets for GEO Profiles (Select 79763517) (1)
GEO DataSets
Model of cerebral aging and Alzheimer's disease: temporal cortex
Model of cerebral aging and Alzheimer's disease: temporal cortex
Accession: GDS4128

GEO DataSets
PCLO piccolo presynaptic cytomatrix protein [Homo sapiens]
PCLO piccolo presynaptic cytomatrix protein [Homo sapiens]
Gene ID:27445

Gene
Gene Links for GEO Profiles (Select 79774260) (1)
Gene

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