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Biological Assay from US Patent US20240083896: "Nitrogen Containing 2,3-Dihydroquinazolinone Compounds as Nav1.8 Inhibitors"
Assay data:22 Active, 15 Activity ≤ 1 µM, 22 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
E-VIPR Assay Detecting and Measuring Nav Inhibition Properties from US Patent US11919887: "Substituted tetrahydrofurans as modulators of sodium channels"
Assay data:54 Active, 107 Activity ≤ 1 µM, 107 Tested
Cross screening panel
Assay data:1 Tested
SummaryRelated BioAssays by Target
Safety47 Scan (DiscoverX - Eurofins)
Sodium Channel, Site 2 Eurofins Panlabs panel
NA+/SITE2/R Eurofins SafetyScreen44 (BI)
Compound was evaluated for inhibition of human SCN5A in an in vitro cell-based assay measured by IonWorks automated patch clamp
Assay data:37 Active, 5 Activity ≤ 1 µM, 230 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Nav1.5 channel (unknown origin) upto 10000 nM
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of TTX-resistant Nav1.8 in mouse dorsal root ganglion neuron by voltage clamp recording
Assay data:2 Tested
Inhibition of TTX-resistant Nav1.8 in mouse dorsal root ganglion neuron at 10 uM by voltage clamp recording relative to control
Inhibition of human Nav1.1 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -40 mV holding potential by PatchXpress automated voltage clamp electrophysiology technique
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of human Nav1.5 alpha subunit expressed in HEK293 cells co-expressing beta1 subunit at -60 mV holding potential by PatchXpress automated voltage clamp electrophysiology technique
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