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Cereblon Binding Assay from US Patent US20240109877: "PYRIMIDINES FOR DEGRADING BRUTON'S TYROSINE KINASE"
Assay data:14 Active, 5 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Compound Activity by Fluorescent Polarization Assay from US Patent US11912682: "Isoindolinone compounds"
Assay data:126 Active, 103 Activity ≤ 1 µM, 155 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Cereblon Binding Assay from US Patent US20240059711: "Cereblon Ligands and Uses Thereof"
Assay data:15 Active, 10 Activity ≤ 1 µM, 15 Tested
Cereblon Binding Assay from US Patent US20240059704: "Cereblon Ligands and Uses Thereof"
Assay data:5 Active, 2 Activity ≤ 1 µM, 5 Tested
In Vitro Assay: IC50 Measurements for Binding to CRBN/DDB1 from US Patent US20240059704: "Cereblon Ligands and Uses Thereof"
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
Fluorescent Polarization Assay from US Patent US20240051936: "ISOINDOLINONE COMPOUNDS"
Assay data:40 Active, 30 Activity ≤ 1 µM, 66 Tested
Inhibition of BRD9 in human Kasumi-1 cells assessed as downregulation of SAMSN1 gene at 1 uM after 6 hrs by qPCR method
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of BRD9 in human Kasumi-1 cells assessed as downregulation of FES gene at 1 uM after 6 hrs by qPCR method
Inhibition of BRD9 in human Kasumi-1 cells assessed as downregulation of DUSP6 gene at 1 uM after 6 hrs by qPCR method
Inhibition of BRD9 in human Kasumi-1 cells assessed as downregulation of CLEC1 gene at 1 uM after 6 hrs by qPCR method
Inhibition of BRD9 in human Kasumi-1 cells assessed as downregulation of SAMSN1 gene at 10 uM after 6 hrs by qPCR method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of BRD9 in human Kasumi-1 cells assessed as downregulation of FES gene at 10 uM after 6 hrs by qPCR method
Inhibition of BRD9 in human Kasumi-1 cells assessed as downregulation of DUSP6 gene at 10 uM after 6 hrs by qPCR method
Inhibition of BRD9 in human Kasumi-1 cells assessed as downregulation of CLEC1 gene at 10 uM after 6 hrs by qPCR method
Protac activity at CRBN/AR in AR-positive human LNCaP cells assessed as induction of androgen receptor degradation at 10 uM incubated for 6 hrs by Western blot analysis (Rvb = 0%)
Assay data:2 Tested
Protac activity at CRBN/AR in AR-positive human LNCaP cells assessed as induction of androgen receptor degradation at 1 uM incubated for 6 hrs by Western blot analysis (Rvb = 0%)
Protac activity at CRBN/AR in AR-positive human LNCaP cells assessed as induction of androgen receptor degradation at 0.1 uM incubated for 6 hrs by Western blot analysis (Rvb = 0%)
PROTAC activity at VHL/BRD9 in human A204 cells assessed as BRD9 protein degradation incubated for 18 hrs by WES capillary electrophoresis analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/BRD9 in human EOL1 cells assessed as BRD9 protein degradation incubated for 18 hrs by WES capillary electrophoresis analysis
PROTAC activity at VHL/HiBit-tagged BRD9 in HEK293 cells assessed as BRD9 protein degradation pre-incubated with endurazine for 2.5 hrs followed by compound addition and measured after 24 hrs by live cell kinetics assay
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