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CDK7/Cyclin HIMAT1 Kinase Inhibitory Activity Assay from US Patent US20240166635: "AMINOHETEROARYL KINASE INHIBITORS"
Assay data:88 Active, 134 Activity ≤ 1 µM, 134 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
CDK Inhibition In Vitro Assay from US Patent US20240150369: "CYCLIN-DEPENDENT KINASE INHIBITING COMPOUNDS FOR THE TREATMENT OF MEDICAL DISORDERS"
Assay data:31 Active, 8 Activity ≤ 1 nM, 31 Activity ≤ 1 µM, 31 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
In Vitro Enzymatic Inhibitory Activity Assay from US Patent US20240132489: "AROMATIC HETEROCYCLIC COMPOUND, PHARMACEUTICAL COMPOSITION, AND USE THEREOF"
Assay data:55 Active, 55 Activity ≤ 1 µM, 55 Tested
In Vitro CDK7 Assay from US Patent US20240109912: "TRICYCLIC PYRIMIDINES AS CYCLIN-DEPENDENT KINASE 7 (CDK7) INHIBITORS"
Assay data:135 Active, 110 Activity ≤ 1 nM, 131 Activity ≤ 1 µM, 135 Tested
Inhibition of recombinant full length human C-terminal His6-tagged CDK7/untagged recombinant full length human Cyclin H/N-terminal GST-tagged recombinant full length human MAT1 expressed in baculovirus infected Sf21 cells using 5-FAM-ACSYSPTSPSYSPTSPSYSPTSPSKK as substrate at 10 uM incubated for 60 mins in presence of ATP relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant full length human C-terminal His6-tagged CDK7/untagged recombinant full length human Cyclin H/N-terminal GST-tagged recombinant full length human MAT1 expressed in baculovirus infected Sf21 cells using 5-FAM-ACSYSPTSPSYSPTSPSYSPTSPSKK as substrate incubated for 60 mins in presence of ATP
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of CDK7 (unknown origin)
Irreversible inhibition of CDK7 (unknown origin) assessed as activity measured after 3 hrs by jump dilution method
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of CDK7 (unknown origin) assessed as phosphorylation of ULight 4EBP1 peptide substrate at 10 uM measured after 2 hrs by FRET-based LANCE Ultra KinSelect assay relative to control
Assay data:2 Tested
Inhibition of CDK7 (unknown origin) assessed as phosphorylation of ULight 4EBP1 peptide substrate measured after 2 hrs by FRET-based LANCE Ultra KinSelect assay
Assay data:30 Active, 14 Activity ≤ 1 µM, 30 Tested
Inhibition of CDK7/Cyclin H/MNAT1 (unknown origin) using 5-FAM-YSPTSPSYSPTSPSYSPTSPSKKK as substrate in presence of ATP by spectroscopic analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of CDK (unknown origin)
Inhibition of CDK7 (unknown origin) by LANCE ULight TR-FRET assay
Inhibition of CDK7 (unknown origin) incubated for 120 mins in presence of ATP by HotSpot kinase assay
Assay data:1 Active, 2 Tested
Inhibition of CDK7 (unknown origin) by Kinomescan method
Inhibition of CDK7 (unknown origin) assessed as substrate phosphorylation using ULight MBP peptide as substrate in presence of ATP incubated for 1 hr by FRET based LANCE Ultra KinaSelect screen assay
Binding affinity to CDK7 (unknown origin) by KINOMEscan method
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
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