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Panlabs assay PDE6
Assay data:1 Tested
SummaryRelated BioAssays by Target
3H-cAMP and 3H-cGMP Scintillation Proximity Assay (PDE6)
Compound was evaluated for inhibition of human PDE6A in an in vitro cell free assay measured by scintillation proximity assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 68 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of PDE6 (unknown origin) by 3H-cAMP scintillation proximity assay
SummaryPubMed CitationRelated BioAssays by Target
Protac activity at VHL/PDE6D in human Jurkat cells at 1 mM incubated for 24 hrs by immunoblotting analysis relative to control
Inhibition of PDE6 (unknown origin) assessed as inhibition constant
Assay data:1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PDE5 Inhibition Assay from US Patent US10626113: "Phosphodiesterase inhibitors and uses thereof"
Assay data:14 Active, 4 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (PDE panel (enzymatic activity assay)) EUB0000751a PDE6A
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Selectivity interaction (PDE panel (enzymatic assay)) EUB0000744a PDE6A
Inhibition of PDE6 (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
Inhibition of PDE6 (unknown origin) using FAM-cGMP or FAM-cAMP as substrate incubated for 60 mins and measured by fluorescence polarization assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of cAMP-specific 3',5'-cyclic phosphodiesterase (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 4 Tested
PROTAC activity at CRBN/PDEdelta in human PancTu-I assessed as induction of PDEdelta degradation incubated for 24 hrs by immunoblot analysis relative to control
PROTAC activity at CRBN/PDEdelta in human PancTu-I assessed as induction of PDEdelta degradation incubated for 24 hrs by immunoblot analysis
Protac activity at PDE delta in human SW480 cells assessed as PDE delta degradation incubated for 24 hrs by western blot analysis
Protac activity at PDE delta in human SW480 cells assessed as PDE delta degradation at 1 uM for 24 hrs by western blot analysis
Assay data:3 Active, 4 Tested
Protac activity at PDE delta in human SW480 cells assessed as PDE delta degradation at 10 uM for 24 hrs by western blot analysis
Assay data:4 Active, 5 Tested
Binding affinity to PDE delta (unknown origin) assessed as dissociation constant measured after 2 hrs by fluorescence polarization assay
Assay data:13 Active, 14 Activity ≤ 1 µM, 14 Tested
Protac activity at CRBN/PDE6D in human MOLT-4 cells assessed as induction of PDE6D degradation at 1 uM measured after 5 hrs by proteome mass spectrometry
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