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GTP-KRAS and cRAF Interaction Assay from US Patent US20240199644: "Fused Ring Derivatives Useful as KRAS G12D Inhibitors"
Assay data:16 Active, 4 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Assay of the Activity of Inhibiting KRASG12D from US Patent US20240174692: "PYRIMIDINE AROMATIC RING COMPOUNDS"
Assay data:10 Active, 3 Activity ≤ 1 nM, 10 Activity ≤ 1 µM, 10 Tested
AlphaScreen Binding Assay from US Patent US20240174690: "ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER"
Assay data:240 Active, 107 Activity ≤ 1 nM, 240 Activity ≤ 1 µM, 240 Tested
Biochemical Functional Assay from US Patent US20240166660: "KRAS G12C INHIBITORS"
Assay data:117 Active, 100 Activity ≤ 1 µM, 126 Tested
Inhibition Test of Compounds on KRAS G12C::SOS1 Binding from US Patent US20240166645: "PYRIDOPYRIMIDINONE DERIVATIVE, PREPARATION METHOD THEREFOR, AND USE THEREOF"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) from US Patent US20240150366: "4-AMINOQUINAZOLINE COMPOUND"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
AlphaScreen Assay from US Patent US20240148821: "PHARMACEUTICAL USE OF CYCLIC PEPTIDE COMPOUND"
Assay data:1791 Active, 341 Activity ≤ 1 nM, 1791 Activity ≤ 1 µM, 1791 Tested
Cdc42 and Rheb GTP Binding Domain Inhibition Assa from US Patent US20240124483: "Methods for the Treatment of Fibrotic Disease"
Assay data:3 Active, 3 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
SOS-Catalyzed Nucleotide Exchange Assay from US Patent US20240124478: "SPIROCYCLIC-SUBSTITUTED 6,7-DIHYDRO-PYRANO[2,3-d]PYRIMIDINE INHIBITORS OF KRAS G12C MUTANT"
Assay data:54 Active, 42 Activity ≤ 1 µM, 54 Tested
KRAS G12C-GDP Exchange Assay from US Patent US20240109893: "PREPARATION AND APPLICATION METHOD OF HETEROCYCLIC COMPOUNDS AS KRAS INHIBITOR"
Assay data:22 Active, 8 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 22 Tested
SOS1 GDP TR-FRET Assay from US Patent US20240092803: "BRIDGED COMPOUNDS AS KRAS G12D INHIBITOR AND DEGRADER AND THE USE THEREOF"
Assay data:14 Active, 12 Activity ≤ 1 µM, 15 Tested
Biochemical Assay 3 from US Patent US20240083857: "2-Methyl-Quinazolines"
Assay data:314 Active, 144 Activity ≤ 1 µM, 367 Tested
Biochemical Assay 2 from US Patent US20240083857: "2-Methyl-Quinazolines"
Assay data:367 Active, 181 Activity ≤ 1 µM, 395 Tested
Biochemical Assay 1 from US Patent US20240083857: "2-Methyl-Quinazolines"
Assay data:372 Active, 198 Activity ≤ 1 µM, 401 Tested
Coupled Nucleotide Exchange Assay from US Patent US20240059703: "HETEROCYCLIC SPIRO COMPOUNDS AND METHODS OF USE"
Assay data:506 Active, 473 Activity ≤ 1 µM, 513 Tested
KRAS::SOS1 AlphaScreen Binding Assay from US Patent US20240051956: "SOS1 INHIBITORS AND USES THEREOF"
Assay data:85 Active, 87 Activity ≤ 1 µM, 87 Tested
SOS-Catalyzed Nucleotide Exchange Assay from US Patent US20240043448: "Small Molecule Inhibitors of KRAS G12C Mutant"
Assay data:93 Active, 7 Activity ≤ 1 nM, 83 Activity ≤ 1 µM, 93 Tested
Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in whole blood pERK level incubated for 4 hrs by HTRF assay
Assay data:6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in pERK level incubated for 4 hrs by HTRF assay
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