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SHP2 Allosteric Inhibition Assay from US Patent US20240199616: "BICYCLIC COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS"
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Phosphatase (PTPase) Assay from US Patent US20240199525: "SHP2-Targeting Small Molecules For Use As Anti-Cancer Agents"
Assay data:6 Active, 2 Activity ≤ 1 µM, 10 Tested
Assay of Full-Length SHP2 Phosphatase Activity Assay from US Patent US20240140931: "TRICYCLIC COMPOUNDS AND USES THEREOF"
Assay data:264 Active, 82 Activity ≤ 1 nM, 272 Activity ≤ 1 µM, 272 Tested
SHP2 Inhibition Enzymatic Assay from US Patent US20240109900: "AZABICYCLIC SHP2 INHIBITORS"
Assay data:519 Active, 511 Activity ≤ 1 µM, 523 Tested
SHP2 Allosteric Inhibition Assay from US Patent US20240092795: "PYRIDINE COMPOUNDS AS ALLOSTERIC SHP2 INHIBITORS"
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Allosteric inhibition of recombinant human SHP2 using IRS1 peptide and DiFMUP as substrate incubated for 30 mins followed by DiFMUP addition and measured after 30 mins by fluorescence based microplate reader analysis
Assay data:35 Active, 33 Activity ≤ 1 µM, 37 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SHP (unknown origin)
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of SHP2 1-525 mutant (unknown origin)
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of SHP2 T253M/Q257L mutant (unknown origin)
Inhibition of SHP2 (unknown origin) E76K mutant
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of wildtype SHP2 (unknown origin)
Assay data:3 Active, 1 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of SHP2 (unknown origin) at 100 mg/mL
Assay data:2 Tested
Inhibition of SHP2 (unknown origin)
Assay data:4 Active, 3 Activity ≤ 1 µM, 6 Tested
Inhibition of SHP2 ( 1 to 525 residues) (unknown origin)
Inhibition of recombinant His-tag fused full length human SHP2 expressed in Escherichia coli BL21 USING pNPP as substrate incubated for 30 mins
Inhibition of SHP2 (unknown origin) using pNPP as substrate by spectrophotometric analysis
Inhibition of recombinant GST-fused human SHP2 (205 to 593 residues) using DiFMUP as substrate incubated for 30 mins by fluorescence based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human His6-tagged wild type SHP2 PTP domain using pNPP as substrate by absorbance based analysis
Inhibition of GST fused SHP2 PTP domain (unknown origin) using EFpYAEVGRSPPDPAK peptide as substrate incubated for 30 mins by malachite green staining based analysis
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