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Radiometric Assay from US Patent US20240140952: "INHIBITORS AND DEGRADERS OF JANUS KINASE 2"
Assay data:15 Active, 9 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical Kinase Assay Protocol (JAK) from US Patent US20240132525: "BORON CONTAINING PYRIMIDINE COMPOUNDS, COMPOSITIONS COMPRISING THEM, METHODS AND USES THEREOF"
Assay data:90 Active, 39 Activity ≤ 1 nM, 91 Activity ≤ 1 µM, 91 Tested
JAK2 Z-Lyte Biochemical Assay from US Patent US20240101559: "TRICYCLIC KINASE INHIBITORS AND USES THEREOF"
Assay data:9 Active, 1 Activity ≤ 1 µM, 11 Tested
Biochemical JAK Kinase Assays from US Patent US20240092758: "IMIDAZOLO INDAZOLE COMPOUNDS AS JAK INHIBITORS"
Assay data:392 Active, 381 Activity ≤ 1 nM, 392 Activity ≤ 1 µM, 392 Tested
In Vitro Test of Activities of Jak1, Jak2, Jak3, Tyk2 Kinases from US Patent US11919896: "[1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and use thereof"
Assay data:34 Active, 22 Activity ≤ 1 µM, 34 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
NanoBRET assay (JAK2, SGC Frankfurt)
Assay data:2 Tested
SummaryRelated BioAssays by Target
Inhibition of JAK2 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of JAK2 (unknown origin) at 1000 nM by by DiscoverX KINOMEscan assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of JAK2 (unknown origin)
Assay data:10 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of JAK2 (unknown origin) at 1 uM relative to control
Inhibition of JAK2 dependent GM-CSF stimulated STAT3 phosphorylation in human TF-1 cells
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of JAK (unknown origin)
Assay data:5 Active, 5 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK2 (unknown origin) by Ambit kinase assay
Assay data:4 Tested
Inhibition of GST-fused JAK2 (808 to 1132 residues) (unknown origin) using Carboxyfluorescein-Ahx-GGEEEEYFELVKKKK peptide as substrate incubated for 60 mins in presence of ATP by Janus kinase assay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
Inhibition of JAK2 (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of full length JAK2 V617F mutant (unknown origin) by JAK radiometric filter binding kinase assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of full length wild type JAK2 (unknown origin) by JAK radiometric filter binding kinase assay
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