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Biochemical CD73 Assay from US Patent US20240140979: "HETEROCYCLIC INHIBITORS OF CD73 FOR TREATMENT OF DISEASE"
Assay data:8 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Biochemical CD73 Assay from US Patent US20240140980: "HETEROCYCLIC INHIBITORS OF CD73 FOR TREATMENT OF DISEASE"
Assay data:29 Active, 15 Activity ≤ 1 nM, 29 Activity ≤ 1 µM, 29 Tested
CD73 Biochemical IC50 Assay from US Patent US20240043427: "CD73 COMPOUNDS"
Assay data:566 Active, 107 Activity ≤ 1 nM, 596 Activity ≤ 1 µM, 596 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:76 Active, 71 Activity ≤ 1 µM, 87 Tested
Inhibition of human N-terminal Ecto-5'-nucleotidase
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
In Vitro Inhibitory Activity of Compound to Recombinant Human CD73 Enzyme from US Patent US20230399314: "CD73 INHIBITOR AND USE THEREOF"
Assay data:20 Active, 17 Activity ≤ 1 µM, 20 Tested
CD73 Enzyme Inhibition Assay from US Patent US20230295213: "CD73 INHIBITORS AND PHARMACEUTICAL USES THEREOF"
Assay data:14 Active, 4 Activity ≤ 1 nM, 14 Activity ≤ 1 µM, 14 Tested
Assay data:18 Active, 19 Activity ≤ 1 µM, 19 Tested
Inhibition of CD73 (unknown origin)
Potency index, ratio of betulinic acid IC50 to test compound IC50 for inhibition of human CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr followed by substrate addition and measured after 2 hrs by malachite green reagent based colorimetric assay
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of mouse CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr followed by substrate addition and measured after 2 hrs by malachite green reagent based colorimetric assay
Assay data:1 Active, 12 Tested
Inhibition of human CD73 assessed as reduction in inorganic phosphate release upon substrate hydrolysis using AMP/ATP as substrate incubated for 1 hr followed by substrate addition and measured after 2 hrs by malachite green reagent based colorimetric assay
Assay data:4 Active, 16 Tested
Inhibition of recombinant human soluble C-terminal His6-tagged CD73 (Trp27 to Lys547 residues) expressed in CHO cells using AMP as substrate measured after 30 mins by capillary electrophoresis
Assay data:1 Tested
Inhibition of 5'-Nucleotidase activity in human tonsils assessed as reduction in CD73 catalytic activity in tonsils incubated for 45 mins in presence of Pb(NO3)2 by H and E staining based assay
Assay data:3 Tested
Inhibition of 5'-Nucleotidase activity in human HN-SCC cells assessed as reduction in tumor CD73 catalytic activity incubated for 45 mins in presence of Pb(NO3)2 by H and E staining based assay
Inhibition of human soluble CD73 at 0.03 to 50000 nM relative to control
Inhibition of human soluble CD73 assessed as inhibition constant
Assay data:21 Active, 7 Activity ≤ 1 nM, 20 Activity ≤ 1 µM, 22 Tested
Inhibition of human recombinant soluble CD73 assessed as inhibition constant by radiometric assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Biochemical Assay from US Patent US11377469: "CD73 inhibitors"
Assay data:113 Active, 132 Activity ≤ 1 µM, 132 Tested
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