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Inhibition of HIV-1 reverse transcriptase
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of HIV-1 reverse transcriptase relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HIV1 reverse transcriptase
Assay data:2 Active, 2 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Time dependent inhibition of recombinant wildtype HIV-1 reverse transcriptase at 0.1 to 1000000 nM
Assay data:3 Tested
Inhibition of recombinant wildtype HIV-1 reverse transcriptase using r(A)350 as template and d(T)16 as primer preincubated with compound for 1 hrs followed by template/primer addition and measured after 30 mins by picogreen based plate reader analysis
Assay data:7 Active, 7 Activity ≤ 1 µM, 13 Tested
Inhibition of HIV-1 reverse transcriptase incubated for 90 mins by liquid scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of wild type recombinant HIV-1 reverse transcriptase using biotin-labelled dNTPs as substrate assessed as inhibition of biotin-labelled UTP incorporation incubated for 1 hr by ELISA
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
Binding affinity to HIV-1 reverse transcriptase assessed as dissociation constant by SPR analysis
Assay data:2 Active, 2 Tested
Inhibition of HIV1 Reverse transcriptase at 25 uM relative to control
Jurkat Latency Reversal Assay from US Patent US11492361: "Compounds useful in HIV therapy"
Assay data:59 Active, 59 Activity ≤ 1 µM, 59 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of recombinant p66/p51 HIV-1 RNase H using 6-FAM-labeld DNA substrate preincubated for 2 mins by fluorescence based assay
Inhibition of HIV-1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as reduction in biotin-dUTP incorporation at 500 nM using poly(A)/oligo (dT)15 as template/primer by ELISA relative to control
Inhibition of HIV-1 reverse transcriptase RNA-dependent DNA polymerase activity assessed as reduction in biotin-dUTP incorporation at 100 nM using poly(A)/oligo (dT)15 as template/primer by ELISA relative to control
Inhibition of HIV1 reverse transcriptase assessed as inhibition of biotin-dUTP incorporation
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant wild-type p66/p51 HIV-1 reverse transcriptase incubated for 40 mins by picogreen dye-based spectrofluorometric analysis
Assay data:32 Active, 19 Activity ≤ 1 µM, 40 Tested
Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction of biotin-dUTP incorporation into protein using ABTS as substrate incubated for 1 hrs by ELISA analysis
Inhibition of wild type HIV-1 reverse transcriptase assessed as reduction in luciferase reporter activity by single-round assay
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of HIV-1 reverse transcriptase using oligo(dT)16 as primer measured after 40 mins by picogreen-dye based spectrofluorometric analysis
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
Potency index, ratio of test compound IC50 to NBD-14189 IC50 for inhibition of recombinant HIV-1 reverse transcriptase incubated for 2 hrs by colorimetric assay
Assay data:15 Tested
Inhibition of recombinant HIV-1 reverse transcriptase incubated for 2 hrs by colorimetric assay
Assay data:8 Active, 1 Activity ≤ 1 µM, 16 Tested
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