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β-Gal Inhibitory Assay from Article 10.1074/jbc.M113.529529: "Structural basis of pharmacological chaperoning for human -galactosidase."
Assay data:1 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition Assay Against Commercial Glycosidases from Article 10.1002/cbic.201300197: "New insights into the pharmacological chaperone activity of c2-substituted glucoimidazoles for the treatment of Gaucher disease."
Assay data:12 Active, 2 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of beta-galactosidase (unknown origin)
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Chaperone activity at beta-galactosidase in GMI-gangliosidosis patient-derived fibroblasts assessed as increase in enzyme activity relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Chaperone activity at beta-galactosidase in mucopolysaccharidosis 4b patient-derived fibroblasts assessed as increase in enzyme activity relative to control
Inhibition of bovine liver beta-galactosidase at 1000 uM
Assay data:2 Tested
Inhibition of wild type C57BL/6 mouse small intestinal lactase using lactose as substrate after 30 mins
Inhibition of beta-galactosidase derived from human HL60 cells assessed as residual activity at 1 mM using 4-MU-Gal as substrate after 30 mins by fluorescence assay
Inhibition of wild type C57BL/6 mouse small intestinal lactase assessed as residual activity at 1 mM using lactose as substrate after 30 mins
Binding affinity to bovine liver beta-galactosidase assessed as induction of changes in enzyme molar ellipticity by CD spectroscopy
Assay data:3 Tested
Competitive inhibition of bovine liver beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside substrate measured over 240 mins at 10 mins intervals by UV/Vis spectroscopy based Eddie-Hofstee plot
Assay data:25 Active, 25 Tested
Competitive inhibition of bovine liver beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside substrate measured over 240 mins at 10 mins intervals by UV/Vis spectroscopy based Lineweaver-Burk plot
Inhibition of bovine liver beta-galactosidase pre-incubated for 30 mins with 4-nitrophenyl-beta-D-galactopyranoside substrate before enzyme addition measured over 45 mins at 27 secs intervals by UV/Vis based spectroscopy
Assay data:25 Active, 20 Activity ≤ 1 nM, 22 Activity ≤ 1 µM, 25 Tested
Inhibition of bovine liver beta-galactosidase using 4-nitrophenyl-beta-D-galactopyranoside substrate measured over 240 mins at 10 mins intervals by UV/Vis spectroscopy
Assay data:20 Active, 19 Activity ≤ 1 µM, 25 Tested
Chaperone activity at beta-galactosidase R201C mutant isolated from human patient fibroblasts assessed as increase increase in thermal stability at 0.2 uM at 48 degC by thermal stability assay
Inhibition of beta-galactosidase R201C mutant isolated from human patient fibroblasts at 1 uM using 4-nitrophenyl beta-D-galactopyranoside as substrat
Chaperone activity at beta-galactosidase R201C mutant isolated from human patient fibroblasts assessed as increase in enzyme activity at 0.2 uM using 4-nitrophenyl beta-D-galactopyranoside as substrate relative to untreated control
Chaperone activity at beta-galactosidase R201C mutant isolated from human patient fibroblasts assessed as increase in enzyme activity at 0.05 uM using 4-nitrophenyl beta-D-galactopyranoside as substrate relative to untreated control
Chaperone activity at beta-galactosidase R201C mutant isolated from human patient fibroblasts assessed as increase in enzyme activity at 10 uM using 4-nitrophenyl beta-D-galactopyranoside as substrate relative to untreated control
Chaperone activity at beta-galactosidase R201C mutant isolated from human patient fibroblasts assessed as increase in enzyme activity at 1 uM using 4-nitrophenyl beta-D-galactopyranoside as substrate relative to untreated control
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