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Displacement of carboxyfluorescein labelled NFATc2 derived PRIEIT peptide from human CNAalpha (2 to 347 residues) at 10 to 100 uM preincubated for 15 mins followed by CF-PRIEIT addition and measured after 15 mins by fluorescence polarization assay
Assay data:9 Active, 9 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human recombinant CNA (2 to 347 residues) phosphatase activity at 50 uM using p-nitrophenyl phosphate as substrate preincubated for 30 mins followed by substrate addition and measured after 30 mins
Assay data:11 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of carboxyfluorescein labelled NFATc2 derived PRIEIT peptide from human CNAalpha (2 to 347 residues) at 10 uM preincubated for 15 mins followed by CF-PRIEIT addition and measured after 15 mins by fluorescence polarization assay
Assay data:2 Active, 2 Tested
Displacement of carboxyfluorescein labelled NFATc2 derived PRIEIT peptide from human CNAalpha (2 to 347 residues) at 100 uM preincubated for 15 mins followed by CF-PRIEIT addition and measured after 15 mins by fluorescence polarization assay
Assay data:4 Active, 11 Tested
Protein Serine/Threonine Phosphatase, Calcineurin, PP2B Eurofins-Panlabs enzyme assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Protein Serine/threonine Phosphatase, PPP3CA (Calcineurin, PP2B) Eurofins-Panlabs enzyme assay
Assay data:2 Tested
Inhibition of human calcineurin activity in PMA/ionomycin-induced human Jurkat cells at 15 uM measured after 44 hrs by Malachite green dye based fast green assay
Assay data:1 Active, 1 Tested
Inhibition of human calcineurin activity in PMA/ionomycin-induced human Jurkat cells measured after 44 hrs by Malachite green dye based fast green assay
Inhibition of recombinant 6His-tagged human calcineurin-alpha expressed in Escherichia coli BL21(DE3/pLysS) assessed as inhibition of calcineurin phosphatase activity by measuring amount of free phosphate at 10 uM preincubated for 20 mins followed by addition of bovine RII phosphopeptide as substrate measured after 30 mins in presence of human calmodulin by malachite green dye-based spectrophotometry relative to DMSO control
Assay data:4 Tested
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
DRUGMATRIX: Protein Serine/Threonine Phosphatase, PPP3CA (Calcineurin, PP2B) enzyme inhibition (substrate: DiFMUP)
Assay data:1 Active, 871 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of human PP2B
Inhibition of human PP2B at 10 uM
Inhibition of protein phosphatase 2B at 10 uM
Inhibition of calcineurin-mediated streptavidin-coupled NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light by luciferase reporter gene assay
Inhibition of calcineurin-mediated streptavidin-coupled NFAT activation in human Jurkat cells by luciferase reporter gene assay
Selectivity ratio of IC50 for calcineurin-mediated NFAT activation in human Jurkat cells to IC50 for calcineurin-mediated NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light
Assay data:3 Tested
Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells measured after 45 min of irradiation with 740 nm light by luciferase reporter gene assay
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of calcineurin-mediated NFAT activation in human Jurkat cells by luciferase reporter gene assay
Reversing Antifungal Drug Resistance Measured in Microorganism System Using Plate Reader - 2037-01_Inhibitor_Dose_DryPowder_Activity
Assay data:18 Active, 2 Activity ≤ 1 µM, 44 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
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