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Binding affinity to HSPA8 in human DOHH-2 cells by MS analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Fluorescence-Polarization (FP) Binding Assay from Article 10.1021/jm101625x: "Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity."
Assay data:14 Active, 4 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
SPR assay from Article 10.1021/jm101625x: "Adenosine-derived inhibitors of 78 kDa glucose regulated protein (Grp78) ATPase: insights into isoform selectivity."
Assay data:13 Active, 8 Activity ≤ 1 µM, 14 Tested
HSP70 Biacore Direct Binding Assay from Article 10.1021/jm801627a: "Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design."
Assay data:7 Active, 6 Activity ≤ 1 µM, 8 Tested
HSP70 Fluorescence Polarization Assay from Article 10.1021/jm801627a: "Novel adenosine-derived inhibitors of 70 kDa heat shock protein, discovered through structure-based design."
Assay data:14 Active, 6 Activity ≤ 1 µM, 17 Tested
Competitive binding affinity to Hsc70 in human BV-173 cell lysate up to 10 uM by pull-down/Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to heat shock 70 kDa protein 1A/1B in human A549 cells by LC-MS/MS analysis
Binding affinity to 78 kDa glucose-regulated protein in human A549 cells by LC-MS/MS analysis
Binding affinity to heat shock cognate 71 kDa protein isoform 1 in human A549 cells by LC-MS/MS analysis
Binding affinity to N-terminal His-tagged GRP78 (unknown origin) assessed as change in melting temperature at 500 uM by differential scanning fluorimetry
Assay data:5 Tested
Binding affinity to human GRP78 at 1 uM measured after 30 mins by UF-ASMS analysis relative to control
Assay data:14 Tested
Covalent inhibition of HSP72-NBD (unknown origin) after by covalent fluorescence polarization assay
Covalent binding affinity to of HSP72-NBD (unknown origin) at 20 uM incubated for 3 hrs at 21 degC by intact protein mass spectrometry
Assay data:1 Active, 2 Tested
Covalent inhibition of HSP72-NBD (unknown origin) assessed as initial inhibition constant nucleotide-derived FP probe displacement based by fluorescence polarization assay
Assay data:2 Active, 5 Tested
Covalent inhibition of HSP72-NBD (unknown origin) assessed as half life (infinity) nucleotide-derived FP probe displacement based by fluorescence polarization assay
Covalent inhibition of HSP72-NBD (unknown origin) assessed as inactivation constant nucleotide-derived FP probe displacement based by fluorescence polarization assay
Covalent inhibition of HSP72-NBD (unknown origin) assessed as Kinact/Ki ratio after 0.33 hrs nucleotide-derived FP probe displacement based by fluorescence polarization assay
Assay data:2 Tested
Covalent inhibition of HSP72-NBD (unknown origin) assessed as Kinact/Ki ratio nucleotide-derived FP probe displacement based by fluorescence polarization assay
Covalent inhibition of HSP72-NBD (unknown origin) assessed as Kinact/Ki ratio after 0.083 to 2 hrs nucleotide-derived FP probe displacement based by fluorescence polarization assay
Covalent inhibition of HSP72-NBD (unknown origin) assessed as Kinact/Ki ratio after 19 hrs nucleotide-derived FP probe displacement based by fluorescence polarization assay
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