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Inhibition of TDP1 (unknown origin) at 100 uM by fluorescence assay
Assay data:34 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human TDP1 measured by real-time oligonucleotide biosensor assay
Assay data:11 Active, 3 Activity ≤ 1 µM, 20 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of TDP1-DNA complex formation in human MCF7 cells at 100 uM by ICE assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of TDP1 (unknown origin) using 5'-Cy5-GATCTAAAAGACTT-pY-3' as substrate measured after 15 mins by gel based fluorescence assay
Assay data:9 Tested
Inhibition of TDP1 (unknown origin) using 5'-FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate at 100 uM measured after 30 mins by fluorescence assay relative to control
Assay data:45 Tested
Induction of TDP1-DNA complex formation in human MCF7 cells at 10 uM by ICE assay
Assay data:2 Tested
Induction of TDP1-DNA complex formation in human MCF7 cells at 10 to 100 uM in presence of TPT by ICE assay
Induction of TDP1-DNA complex formation in human MCF7/TDP1 cells at 10 uM by ICE assay
Induction of TDP1-DNA complex formation in human MCF7/TPD1 cells at 10 to 100 uM in presence of TPT by ICE assay
Gel-based Assay from US Patent US9402842: "Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (Tdp1)—topoisomerase I (Top1) inhibitors"
Assay data:4 Active, 12 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Gel-Based Assay from US Patent US8912213: "Synthesis and use of dual tyrosyl-DNA phosphodiesterase I (TDP1)- topoisomerase I (TOP1) inhibitors"
Gel-Based Assay from US Patent US8865686: "Tetracycline compounds as tyrosyl-DNA phosphodiesterase I inhibitors"
Assay data:1 Active, 8 Tested
Inhibition of recombinant TDP1 (unknown origin) expressed in Escherichia coli using 5'-FAM/3'-BHQ1 tagged oligonucleotide as substrate by fluorescence assay
Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested
Inhibition of TDP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) at 100 uM using 5'-FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay relative to control
Assay data:26 Tested
Inhibition of TDP1 (unknown origin) expressed in Escherichia coli BL21 (DE3) using 5'-FAM-AGGATCTAAAAGACTT-BHQ-3' as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
Assay data:21 Tested
Inhibition of TDP1 (unknown origin) using 5'-(5,6 FAM-AAC GTC AGG GTC TTC C- BHQ1)-3' as substrate measured after 20 mins by gel-based assay
Inhibition of TDP1 (unknown origin) using 5'-(5,6 FAM-AAC GTC AGG GTC TTC C- BHQ1)-3' as substrate measured for every 1 min by fluorescence based assay
Assay data:12 Active, 6 Activity ≤ 1 µM, 17 Tested
Inhibition of N-terminal His-tagged TDP1 (unknown origin) expressed in Escherichia coli BL21(DE3) using 5'-6-FAM-AGGATCTAAAAGACTT-3BHQ-3' as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant TDP1 (unknown origin) using 5'-32P-labeled N14Y DNA substrate incubated for 15 mins by PAGE analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 4 Tested
Inhibition of recombinant TDP1 (unknown origin) using 5'-32P-labeled N14Y DNA substrate incubated for 20 mins by PAGE analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
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