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Inhibition of porcine PDHc E1-subunit assessed as DCPIP reduction at 250 uM preincubated for 30 mins followed by pyruvate addition using 125 uM ThDP as substrate by microplate reader analysis
Assay data:12 Tested
SummaryRelated BioAssays by Target
Ratio of Km for ThDP substrate activity at porcine PDHc E1-subunit to Ki for inhibition of porcine PDHc E1-subunit assessed as inhibition constant preincubated for 30 mins followed by pyruvate addition using 10 uM ThDP as substrate by microplate reader analysis
Assay data:3 Tested
Inhibition of porcine PDHc E1-subunit assessed as inhibition constant preincubated for 30 mins followed by pyruvate addition using 10 uM ThDP as substrate by microplate reader analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of porcine PDHc E1-subunit assessed as DCPIP reduction preincubated for 30 mins followed by pyruvate addition using 10 uM ThDP as substrate by microplate reader analysis
Assay data:3 Active, 3 Tested
Inhibition of porcine PDHc E1-subunit assessed as DCPIP reduction at 250 uM preincubated for 30 mins followed by pyruvate addition using 50 uM ThDP as substrate by microplate reader analysis
Assay data:32 Tested
Inhibition of pig heart PDHc-E1 using sodium pyruvate as substrate at 100 uM after 3 mins by 2,6-DCPIP based microplate reader method
Assay data:4 Tested
SummaryPubMed CitationRelated BioAssays by Target
Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB
Assay data:3916 Active, 206 Activity ≤ 1 nM, 1830 Activity ≤ 1 µM, 3916 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Binding affinity to mitochondrial pyruvate dehydrogenase E1 component subunit alpha in Sprague-Dawley rat heart homogenate after 15 mins by chromatographic analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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