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Activation of GLP2 receptor transfected in human HEK293 cells assessed as increase in intracellular cAMP level at 1 nM
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Binding affinity towards GLP-2 receptor in human HEK293 cells measured by fluorescence assay
Assay data:9 Active, 3 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
PRESTO-Tango GPCRome screening (GLP2R)
Assay data:1 Tested
SummaryRelated BioAssays by Target
Agonist activity at human GLP-2 receptor expressed in CHO-K1 cells assessed as cAMP induction by FRET assay
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human GLP2 receptor expressed in HEK293 cells assessed as increase in intracellular cAMP accumulation by AlphaScreen assay
Assay data:14 Active, 13 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 15 Tested
Antagonist activity at GLP2R (unknown origin) at 10 uM by cAMP accumulation based assay relative to control
SummaryPubMed CitationRelated BioAssays by Target
Agonist activity at GLP2R (unknown origin) at 10 uM by cAMP accumulation based assay relative to control
Rat GLP-2 receptor (Glucagon receptor family)
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human GLP-2 receptor (Glucagon receptor family)
Assay data:4 Active, 4 Tested
Agonist activity at rat GLP2R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay
Potency index, ratio of compound EC50 to compound 2 EC50 for human GLP2R expressed in HEK293 cells
Assay data:29 Tested
Agonist activity at human GLP2R expressed in HEK293 cells after 5 hrs by luciferase reporter gene assay
Assay data:93 Active, 79 Activity ≤ 1 nM, 95 Activity ≤ 1 µM, 95 Tested
Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as reduction of GLP2-induced cAMP level at 3 to 10 uM after 30 mins
Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation at 50 uM measured on day 3 by Alamar Blue assay relative to 100 pM GLP2
Assay data:8 Tested
Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation at 25 uM measured on day 3 by Alamar Blue assay relative to 10 pM GLP2
Assay data:28 Tested
Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation at 50 uM measured on day 3 by Alamar Blue assay relative to 10 pM GLP2
Assay data:7 Tested
Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation at 25 uM measured on day 3 by Alamar Blue assay relative to 100 pM GLP2
Assay data:38 Tested
Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation measured on day 3 by Alamar Blue assay
Assay data:3 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 19 Tested
Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation at 12.5 uM measured on day 3 by Alamar Blue assay relative to 100 pM GLP2
Assay data:12 Tested
Positive ago-allosteric modulation of GLP2R overexpressed in human SE302 cells assessed as placental alkaline phosphatase activation at 6.3 uM measured on day 3 by Alamar Blue assay relative to 10 pM GLP2
Assay data:2 Tested
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