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Potency index, ratio of 2-(4-(6-methoxynaphthalen-2-yl)phenyl)-4-methylmorpholin-2-ol hydrobromide IC50 to compound IC50 for inhibition of SQS in rat liver microsomes
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Potency index, ratio of 4-methyl-2-(4-(naphthalen-2-yl)phenyl)morpholin-2-ol hydrobromide IC50 to compound IC50 for inhibition of SQS in rat liver microsomes
Potency index, ratio of 2-(biphenyl-4-yl)-4-methylmorpholin-2-ol hydrobromide IC50 to compound IC50 for inhibition of SQS in rat liver microsomes
Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene after 45 mins by liquid scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of SQS in rat liver microsomes assessed as reduction in [3H]FPP conversion to squalene preincubated for 10 mins followed by [3H]FPP addition and measured after 10 mins by scintillation counting method
Assay data:6 Active, 3 Activity ≤ 1 µM, 19 Tested
Inhibition of SQS in rat microsomes using [3H]-FPP as substrate preincubated for 10 mins followed by substrate addition measured after 30 mins by scintillation counting
Assay data:3 Active, 1 Activity ≤ 1 µM, 17 Tested
Human squalene synthase (Lanosterol biosynthesis pathway)
Assay data:27 Active, 27 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Rat squalene synthase (Lanosterol biosynthesis pathway)
Assay data:58 Active, 58 Tested
Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene incubated for 30 mins by liquid scintillation counting
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene at 50 uM incubated for 30 mins by liquid scintillation counting
Inhibition of squalene synthase in rat liver microsomes assessed as reduction in conversion of [3H]farnesyl pyrophosphate to squalene at 10 uM incubated for 30 mins by liquid scintillation counting method
Assay data:14 Tested
Inhibition of human SQS
Inhibition of squalene synthase in rat liver microsomes assessed as decrease in conversion of [3H]FPP to squalene
Assay data:8 Active, 22 Tested
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of rat hepatic microsomal squalene synthase using [3H]FPP as substrate after by scintillation spectrophotometry
Assay data:9 Active, 3 Activity ≤ 1 nM, 9 Activity ≤ 1 µM, 9 Tested
Inhibition of squalene synthase in rat liver microsomes assessed as inhibition of [3H] FPP conversion to squalene after 10 mins by scintillation counting analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of human squalene synthase
Inhibition of squalene synthase in rat hepatic cells
Assay data:42 Active, 9 Activity ≤ 1 nM, 44 Activity ≤ 1 µM, 44 Tested
Inhibition of rat microsomal squalene synthase activity assessed as conversion of [3H]FPP to squalene
Assay data:2 Active, 5 Tested
Inhibition of squalene synthase in Wistar Charles River rat assessed as formation of squalene using [3H]FPP as substrate after 20 mins by scintillation counting
Assay data:23 Active, 23 Activity ≤ 1 µM, 23 Tested
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