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Toxicity index, ratio of test compound TC50 to polymyxin B TC50 for cytotoxicity against human differentiated conditionally immortalized RPTEC cells incubated for 24 hrs by PrestoBlue reagent based assay
Assay data:17 Tested
SummaryPubMed Citation
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 assessed as inhibition of bacterial growth by CLSI based broth microdilution method
Assay data:29 Tested
Antibacterial activity against Acinetobacter baumannii ATCC 19606 assessed as inhibition of bacterial growth by CLSI based broth microdilution method
Antibacterial activity against Klebsiella pneumoniae ATCC 13883 assessed as inhibition of bacterial growth by CLSI based broth microdilution method
Antibacterial activity against Escherichia coli ATCC 25922 assessed as inhibition of bacterial growth by CLSI based broth microdilution method
Potentiation of novobiocin-induced antibacterial activity against novobiocin and colistin resistant Acinetobacter baumannii ATCC 17978 mutant generated from seven serial passages by checkerboard assay
Assay data:2 Tested
Toxicity in Galleria mellonella larvae MDR Acinetobacter baumannii isolate assessed as larvae protection at 25 mg/kg in combination with novobiocin measured after 24 to 96 hrs relative to control
Assay data:1 Tested
Induction of outer membrane permeabilization in Pseudomonas aeruginosa PAO1 assessed as increase in accumulation of NPN by measuring fluorescence intensity at 8 ug/ml measured immediately by NPN dye uptake assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Potentiation of novobiocin-induced antibacterial activity against colistin-resistant Enterobacter cloacae 118568 clinical solate assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 1024 ug/ml)
Potentiation of novobiocin-induced antibacterial activity against colistin-resistant Klebsiella pneumoniae 113254 clinical isolate assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 256 ug/ml)
Potentiation of novobiocin-induced antibacterial activity against colistin-resistant Escherichia coli 94474 clinical isolate harboring mcr-1 gene assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 256 ug/ml)
Potentiation of novobiocin-induced antibacterial activity against colistin-resistant Acinetobacter baumannii 92247 clinical isolate assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 4 ug/ml)
Potentiation of novobiocin-induced antibacterial activity against colistin-resistant Escherichia coli 94393 clinical isolate harboring mcr-1 gene assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 128 ug/ml)
Potentiation of novobiocin-induced antibacterial activity against carbapenem and colistin-resistant Pseudomonas aeruginosa 114228 clinical isolate assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 512 ug/ml)
Potentiation of novobiocin-induced antibacterial activity against colistin and carbapenem-resistant Pseudomonas aeruginosa 101243 clinical isolate assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 128 ug/ml)
Potentiation of novobiocin-induced antibacterial activity against carbapenem and colistin-resistant Pseudomonas aeruginosa 91433 clinical isolate assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 16 ug/ml)
Potentiation of novobiocin-induced antibacterial activity against wild type Pseudomonas aeruginosa PAO1 assessed as novobiocin MIC at <= 7.1 uM incubated for 18 hrs by CLSI protocol based assay (Rvb = 512 ug/ml)
Assay data:3 Tested
Induction of membrane permeability in multidrug resistant Enterobacter aerogenes EA289 over-expressing AcrAB-TolC assessed as nitrocefin hydrolysis at 0.75 to 48 uM after 1 hr in presence of CCCP
Antibacterial activity against Acinetobacter baumannii BAA-1605 after 16 to 18 hrs by CLSI method
Assay data:38 Tested
Antibacterial activity against Escherichia coli ATCC 25922 after 16 to 18 hrs by CLSI method
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