BioAssays for PubChem Compound (Select 137796294) - PubChem BioAssay - NCBI

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Select item 19634981.

HTS to identify compounds that affect the blood-brain barrier permeability in vitro

Source:: Burek Lab, Department of Anaesthesiology, Intensive Care, Emergency and Pain Med, University Hospital Wuerzburg

Assay data:419 Active, 1260 Tested

AID:: 1963498

Summary Compounds, Active

Select item 19154172.

Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915417

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19154163.

Selectivity interaction (Kinobead pulldown assay ) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1915416

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19154154.

Selectivity interaction (DSF assay) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Tested

AID:: 1915415

Summary Related BioAssays by Target

Select item 19154145.

Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1915414

Summary Related BioAssays by Target

Select item 19154136.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000232b SYK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase SYK

Assay data:1 Tested

AID:: 1915413

Summary Related BioAssays by Target

Select item 19154127.

Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b LCK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lck

Assay data:1 Tested

AID:: 1915412

Summary Related BioAssays by Target

Select item 19154118.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000232b LCK

Source:: ChEMBL

Protein Target:: Tyrosine-protein kinase Lck

Assay data:1 Tested

AID:: 1915411

Summary Related BioAssays by Target

Select item 19154109.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000232b EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Tested

AID:: 1915410

Summary Related BioAssays by Target

Select item 191540910.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000232b EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Tested

AID:: 1915409

Summary Related BioAssays by Target

Select item 191540811.

Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Tested

AID:: 1915408

Summary Related BioAssays by Target

Select item 191540712.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000232b EGFR

Source:: ChEMBL

Protein Target:: Epidermal growth factor receptor

Assay data:1 Tested

AID:: 1915407

Summary Related BioAssays by Target

Select item 191540613.

Selectivity interaction (ScanMAX (DiscoverX, competition-binding assay)) EUB0000232b SLK

Source:: ChEMBL

Protein Target:: STE20-like serine/threonine-protein kinase

Assay data:1 Tested

AID:: 1915406

Summary Related BioAssays by Target

Select item 191540514.

Selectivity interaction (ScanMAX (DiscoverX)) EUB0000232b SLK

Source:: ChEMBL

Protein Target:: STE20-like serine/threonine-protein kinase

Assay data:1 Tested

AID:: 1915405

Summary Related BioAssays by Target

Select item 191336415.

Affinity Biochemical interaction (RapidFire MS assay) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913364

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191336316.

Affinity Biochemical interaction (RapidFire MS assay) EUB0000232b LIMK2

Source:: ChEMBL

Protein Target:: LIM domain kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913363

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191305117.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000232b LIMK1

Source:: ChEMBL

Protein Target:: LIM domain kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913051

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191305018.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000232b LIMK2

Source:: ChEMBL

Protein Target:: LIM domain kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913050

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 185747919.

Microsomal stability in human liver microsomes assessed as intrinsic clearance at 4 uM incubated for 30 mins in presence of NADPH by LCMS/MS analysis

Source:: ChEMBL

Assay data:7 Tested

AID:: 1857479

Summary PubMed Citation

Select item 185747820.

Microsomal stability in rat liver microsomes assessed as intrinsic clearance at 4 uM incubated for 30 mins in presence of NADPH by LCMS/MS analysis

Source:: ChEMBL

Assay data:7 Tested

AID:: 1857478

Summary PubMed Citation

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BioActivity

Active Compounds (26)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 µM (24)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (29)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (27)
BioAssays extracted from the literature
Other (44)
BioAssays deposited by other experimentalists

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gi|776395|gnl|dbEST|191631|gb|R2161

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