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Co-operative binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as maximal intensity in the presence of BRD9-BD as complex with compound incubated for 1 hrs by AlphaLISA proximity assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Negative co-operative binding affinity to 6His-tagged human VHL/ElonginC/ElonginB expressed in Escherichia coli BL21 (DE3) cells assessed as total gibb's free energy change in the presence of BRD9-BD as complex with compound by ITC analysis
Assay data:2 Tested
PROTAC activity at VHL/BRD9 in human A204 cells assessed as BRD9 protein degradation incubated for 18 hrs by WES capillary electrophoresis analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
PROTAC activity at VHL/BRD9 in human EOL1 cells assessed as BRD9 protein degradation incubated for 18 hrs by WES capillary electrophoresis analysis
PROTAC activity at VHL/HiBit-tagged BRD9 in HEK293 cells assessed as BRD9 protein degradation pre-incubated with endurazine for 2.5 hrs followed by compound addition and measured after 24 hrs by live cell kinetics assay
PROTAC activity at VHL/HiBit-tagged BRD7 in HEK293 cells assessed as BRD7 protein degradation pre-incubated with endurazine for 2.5 hrs followed by compound addition and measured after 24 hrs by live cell kinetics assay
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as maximal degradation by Western blot analysis relative to control
Assay data:1 Tested
PROTAC activity at VHL/BRD9 in human Ri-1 cells assessed as maximal degradation by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 100 nM incubated for 48 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 10 nM incubated for 48 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as degradation of BRD7 protein incubated for 8 hrs by Western blot analysis
PROTAC activity at VHL/BRD9 in human Ri-1 cells assessed as degradation of BRD9 protein incubated for 8 hrs by Western blot analysis
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 1 nM incubated for 2 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 10 nM incubated for 2 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 100 nM incubated for 2 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 10000 nM incubated for 2 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 0.1 nM incubated for 8 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 1 nM incubated for 8 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 10 nM incubated for 8 hrs by Western blot analysis relative to control
PROTAC activity at VHL/BRD7 in human Ri-1 cells assessed as remaining BRD7 protein level at 100 nM incubated for 8 hrs by Western blot analysis relative to control
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