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Cytotoxicity against human OCILY10 cells assessed as reduction in cell viability measured after 12 days by CellTiter-Glo assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cytotoxicity against human HBL1 cells assessed as reduction in cell viability measured after 12 days by CellTiter-Glo assay
Induction of apoptosis in human HBL1 cells assessed as increase in PARP cleavage at up to 1 uM measured after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of IRAK1 in human HBL1 cells assessed as reduction in total STAT3 level at up to 1 uM measured after 24 hrs by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of IRAK1 in human HBL1 cells assessed as reduction in phosphorylated STAT3 level at up to 1 uM measured after 24 hrs by Western blot analysis
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of IRAK1 in human HBL1 cells assessed as reduction in phosphorylated IKBA level at up to 1 uM measured after 24 hrs by Western blot analysis
Protac activity at IRAK1/VHL E3 ligase in human OCILY10 assessed as induction of IRAK1 degradation measured after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Protac activity at IRAK1/VHL E3 ligase in human HBL1 assessed as induction of IRAK1 degradation measured after 24 hrs by Western blot analysis
Induction of GAK degradation in human Toledo cells at 1 uM measured after 6 hrs by quantitative mass spectrometry relative to control
Inhibition of wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system at 1 uM by Kinomescan method relative to control
Induction of NMRAL1 degradation in human Toledo cells assessed as decrease in protein abundance at 1 uM measured after 6 hrs by quantitative mass spectrometry
Induction of GAK degradation in human Toledo cells assessed as decrease in protein abundance at 1 uM measured after 6 hrs by quantitative mass spectrometry
Induction of IRAK1 degradation in human Toledo cells assessed as decrease in protein abundance at 1 uM measured after 6 hrs by quantitative mass spectrometry
Inhibition of wild-type human partial length YSK4 (T1019 to H1328 residues) expressed in mammalian expression system at 1 uM by Kinomescan method
Inhibition of wild-type human full length DRAK2 (M1 to C372 residues) expressed in bacterial expression system at 1 uM by Kinomescan method
Inhibition of wild-type human partial length BIKE (S34 to N329 residues) expressed in bacterial expression system at 1 uM by Kinomescan method
Protac activity at IRAK1/VHL E3 ligase in HEK293T cells assessed as induction of IRAK1 degradation at 1 uM measured after 24 hrsin presence of VH298 by Western blot analysis
Protac activity at IRAK1/VHL E3 ligase in HEK293T cells assessed as induction of IRAK1 degradation at 1 uM measured after 24 hrsin presence of proteasome inhibitior MG-132 by Western blot analysis
Displacement of 5-FAM-labelled DEALA-HypYIPMDDDFQLRSF peptide from VHL (unknown origin) by fluorescence polarization assay
Assay data:3 Active, 4 Tested
Protac activity at IRAK1/VHL E3 ligase in HEK293T cells assessed as induction of IRAK1 degradation measured after 24 hrs by Western blot analysis
Assay data:3 Active, 3 Activity ≤ 1 µM, 4 Tested
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