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Toxicity in po dosed BALB/c mouse assessed as mean lethal dose
Assay data:1 Tested
SummaryPubMed Citation
Neuroprotective activity against MPTP/probenedcic-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in DOPA decarboxylase expression in SNpc at 1 to 2 mg/kg, ig pretreated with MPTP/probenecid for 32 days followed by compound addition for next 20 days and measured after 20 days by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Neuroprotective activity against MPTP-induced DAergic neuron loss in ig dosed C57BL/6 mouse model of Parkinson's disease assessed as decrease in caspase-3 level in striatum pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by western blot analysis
Neuroprotective activity against MPTP-induced DAergic neuron loss in ig dosed C57BL/6 mouse model of Parkinson's disease assessed as decrease in caspase-9 level in striatum pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by western blot analysis
Neuroprotective activity against MPTP-induced DAergic neuron loss in ig dosed C57BL/6 mouse model of Parkinson's disease assessed as increase in Bcl2/Bax ratio level in striatum pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by western blot analysis
Neuroprotective activity in against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in tyrosine hydroxylase level in striatum at 1 to 2 mg/kg,ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Immunoblotting method
Neuroprotective activity in against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in tyrosine hydroxylase level in striatum at 1 to 2 mg/kg,ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Immunohistochemistry method
Neuroprotective activity against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as decrease in NO level in striatum at 1 to 2 mg/kg, ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Griess reagent based assay
Neuroprotective activity against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in DA level in striatum at 1 to 2 mg/kg, ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by ELISA
Neuroprotective activity in against MPTP-induced DAergic neuron loss in C57BL/6 mouse model of Parkinson's disease assessed as increase in tyrosine hydroxylase level in SNpc at 1 to 2 mg/kg,ig pretreated for 10 days followed by MPTP challenge and measured 10 days post MPTP challenge by Immunoblotting method
Toxicity in BALB/c mouse assessed as adverse effects in lung at 1000 mg/kg, po administered for 14 days by HE staining based assay
Toxicity in BALB/c mouse assessed as adverse effects in spleen at 1000 mg/kg, po administered for 14 days by HE staining based assay
Toxicity in BALB/c mouse assessed as adverse effects in liver at 1000 mg/kg, po administered for 14 days by HE staining based assay
Toxicity in BALB/c mouse assessed as adverse effects in heart at 1000 mg/kg, po administered for 14 days by HE staining based assay
Toxicity in BALB/c mouse assessed as adverse effects in kidney at 1000 mg/kg, po administered for 14 days by HE staining based assay
Cmax in Balb/c mouse brain at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cmax in Balb/c mouse blood at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis
Assay data:1 Active, 2 Tested
Half life in Balb/c mouse brain at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis
Assay data:2 Tested
Half life in Balb/c mouse blood at 30 mg/kg, po administered as single dose measured upto 24 hrs by LC-MS analysis
Effective permeability of compound in PBS at pH 7.4 at 200 uM incubated for 17 hrs by PAMPA-BBB assay
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